Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.3.5.2 extracted from

  • Deras, M.L.; Chittur, S.V.; Davisson, V.J.
    N2-hydroxyguanosine 5'-monophosphate is a time-dependent inhibitor of Escherichia coli guanosine monophosphate synthetase (1999), Biochemistry, 38, 303-310.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
2-fluoroinosine 5'-monophosphate 50% inhibition above 2 mM Escherichia coli
6-Thio-GMP
-
Escherichia coli
8-aza-GMP
-
Escherichia coli
GMP 0.33 mM, 50% inhibition Escherichia coli
N2-hydroxyguanosine 5'-monophosphate 0.0003-0.0005 mM, 50% inhibition Escherichia coli
oxanosine
-
Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required for activity Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + xanthosine 5'-phosphate + L-glutamine + H2O Escherichia coli
-
AMP + diphosphate + GMP + L-glutamate
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant GMPS Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + xanthosine 5'-phosphate + L-glutamine + H2O
-
Escherichia coli AMP + diphosphate + GMP + L-glutamate
-
?

Synonyms

Synonyms Comment Organism
GMPS
-
Escherichia coli
guanosine monophosphate synthetase
-
Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000092
-
N2-hydroxyguanosine 5'-monophosphate competitive vs XMP Escherichia coli
0.33
-
GMP
-
Escherichia coli
0.4
-
8-aza-GMP
-
Escherichia coli
0.74
-
oxanosine
-
Escherichia coli
3
-
6-Thio-GMP
-
Escherichia coli