Literature summary for 6.3.5.2 extracted from

Zalkin, H.; Truitt, C.D.
Characterization of the glutamine site of Escherichia coli guanosine 5'-monophosphate synthetase (1977), J. Biol. Chem., 252, 5431-5436.

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Inhibitors

Inhibitors	Comment	Organism	Structure
6-diazo-5-oxo-L-norleucine	inhibition of Gln-dependent activity and NH4+-dependent activity	Escherichia coli
iodoacetamide	inhibition of Gln-dependent activity, no inhibition of NH4+-dependent activity	Escherichia coli
L-2-Amino-4-oxo-5-chloropentanoic acid	inhibition of Gln-dependent activity and NH4+-dependent activity	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + XMP + Gln	-	Escherichia coli	AMP + diphosphate + GMP + Glu	-	?
ATP + XMP + NH4+	-	Escherichia coli	AMP + diphosphate + GMP	-	?
additional information	glutaminase activity	Escherichia coli	?	-	?

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Release 2023.1 (January 2023)