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Literature summary for 6.3.5.2 extracted from

  • Nakamura, J.; Lou, L.
    Biochemical characterization of human GMP synthetase (1995), J. Biol. Chem., 270, 7347-7353.
    View publication on PubMed

Application

Application Comment Organism
synthesis importance of guanine synthesis in immune cell function, GMP synthetase is a potential target for immunosuppressive therapy Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-chloroadenosine
-
Homo sapiens
3'-dAMP
-
Homo sapiens
5'-deoxyadenosine
-
Homo sapiens
6-Amino-9-D-psicofuranosylpurine
-
Homo sapiens
AMP poor product inhibitor, competitive towards ATP Homo sapiens
ATPgammaS
-
Homo sapiens
beta,gamma-Imidoadenosine 5-triphosphate
-
Homo sapiens
Decoyinine uncompetitive towards Gln and XMP and noncompetitive towards ATP Homo sapiens
diphosphate
-
Homo sapiens
glutamic acid-gamma-methyl ester competitive towards Gln Homo sapiens
GMP
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.132
-
ATP
-
Homo sapiens
0.406
-
Gln
-
Homo sapiens
5.1
-
NH4+
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ depends on MgATP2-, but additionally requires free Mg2+ Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + XMP + Gln
-
Homo sapiens AMP + diphosphate + GMP + Glu
-
?
ATP + XMP + NH4+
-
Homo sapiens AMP + diphosphate + GMP
-
?
ATPgammaS + XMP + Gln GMP formation is 10% that of ATP Homo sapiens ?
-
?
additional information glutaminase activity Homo sapiens ?
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
additional information
-
Homo sapiens