Application | Comment | Organism |
---|---|---|
synthesis | importance of guanine synthesis in immune cell function, GMP synthetase is a potential target for immunosuppressive therapy | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-chloroadenosine | - |
Homo sapiens | |
3'-dAMP | - |
Homo sapiens | |
5'-deoxyadenosine | - |
Homo sapiens | |
6-Amino-9-D-psicofuranosylpurine | - |
Homo sapiens | |
AMP | poor product inhibitor, competitive towards ATP | Homo sapiens | |
ATPgammaS | - |
Homo sapiens | |
beta,gamma-Imidoadenosine 5-triphosphate | - |
Homo sapiens | |
Decoyinine | uncompetitive towards Gln and XMP and noncompetitive towards ATP | Homo sapiens | |
diphosphate | - |
Homo sapiens | |
glutamic acid-gamma-methyl ester | competitive towards Gln | Homo sapiens | |
GMP | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.132 | - |
ATP | - |
Homo sapiens | |
0.406 | - |
Gln | - |
Homo sapiens | |
5.1 | - |
NH4+ | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | depends on MgATP2-, but additionally requires free Mg2+ | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + XMP + Gln | - |
Homo sapiens | AMP + diphosphate + GMP + Glu | - |
? | |
ATP + XMP + NH4+ | - |
Homo sapiens | AMP + diphosphate + GMP | - |
? | |
ATPgammaS + XMP + Gln | GMP formation is 10% that of ATP | Homo sapiens | ? | - |
? | |
additional information | glutaminase activity | Homo sapiens | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Homo sapiens |