Cloned (Comment) | Organism |
---|---|
overexpressed in Escherichia coli BL21 (DE3) | Mus musculus |
Crystallization (Comment) | Organism |
---|---|
crystals grown by the method of hanging drops, space group P4(#)2(1)2, a = b = 69.93, c = 198.49 | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.012 | - |
GTP | pH 7.2, 22°C | Mus musculus | |
0.045 | - |
IMP | pH 7.2, 22°C | Mus musculus | |
0.14 | - |
L-aspartate | pH 7.2, 22°C | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + IMP + L-aspartate | Mus musculus | catalyzes the first committed step in the de novo biosynthesis of AMP | GDP + phosphate + adenylosuccinate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
mouse | - |
Purification (Comment) | Organism |
---|---|
- |
Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + IMP + L-aspartate | - |
Mus musculus | GDP + phosphate + adenylosuccinate | - |
? | |
GTP + IMP + L-aspartate | catalyzes the first committed step in the de novo biosynthesis of AMP | Mus musculus | GDP + phosphate + adenylosuccinate | - |
? | |
additional information | vertebrates possess two isozymes, the acidic is similar to the synthetase from bacteria and plants, the basic isozyme participates in the purine nucleotide cycle | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Adenylosuccinate synthetase | - |
Mus musculus |
mouse muscle synthetase | - |
Mus musculus |