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Literature summary for 6.3.4.4 extracted from
- Specificity of adenylosuccinate synthetase and adenylosuccinate lyase from Leishmania donovani. Selective amination of an antiprotozoal agent (1979), J. Biol. Chem., 254, 8422-8426.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (NH4)2SO4 | 25 mM | Leishmania donovani |  |
| 2'-GMP | - |
Leishmania donovani | |
| 3'-GMP | - |
Leishmania donovani | |
| 6-Thio-GMP | - |
Leishmania donovani | |
| 8-Aza-7-deaza-GMP | - |
Leishmania donovani | |
| 8-aza-GMP | - |
Leishmania donovani | |
| acyclo-GMP | - |
Leishmania donovani | |
| arabinosyl-GMP | - |
Leishmania donovani | |
| cyclic GMP | - |
Leishmania donovani | |
| dGMP | 2'-dGMP | Leishmania donovani | |
| GMP | and analogs | Leishmania donovani | |
| KCl | 75 mM | Leishmania donovani | |
| phosphoenolpyruvate | - |
Leishmania donovani | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.012 | - |
GTP | IMP | Leishmania donovani | |
| 0.05 | - |
8-azaIMP | - |
Leishmania donovani | |
| 0.26 | - |
arabinosylIMP | - |
Leishmania donovani | |
| 0.34 | - |
allopurinol ribonucleotide | - |
Leishmania donovani | |
| 0.48 | - |
2'-dIMP | - |
Leishmania donovani | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 250000 | - |
gel filtration | Leishmania donovani |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Leishmania donovani | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + 2'-dIMP + L-Asp | - |
Leishmania donovani | GDP + phosphate + 2'-deoxysuccinoAMP | - |
? | |
| GTP + 4-hydroxypyrazolo[3,4-d]pyrimidine ribonucleotide + L-Asp | i.e. allopurinol ribonucleotide | Leishmania donovani | GDP + phosphate + 4-aminopyrazolo[3,4-d]pyrimidine ribonucleotide | - |
? | |
| GTP + 8-azaIMP + L-Asp | - |
Leishmania donovani | GDP + phosphate + 8-azasuccinoAMP | - |
? | |
| GTP + beta-D-arabinosylIMP + L-Asp | - |
Leishmania donovani | GDP + phosphate + arabinosylsuccinoAMP | - |
? | |
| GTP + IMP + L-Asp | - |
Leishmania donovani | GDP + phosphate + adenylosuccinate | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.3 | 6.8 | - |
Leishmania donovani |
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