Application | Comment | Organism |
---|---|---|
pharmacology | the enzyme might be a target for colorectal cancer therapy | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene DKFZp586G1517, DNA and amino acid sequence determination and analysis, overexpression of mitochondrial enzyme in HEK-293 cells, unlabeled or FLAG-tagged, stimulates cell growth | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | mitochondrial isozyme, contains an N-terminal mitochondrial targeting sequence | Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme may participate in the progression of colorectal cancer by conferring growth advantage | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q6UB35 | trifunctional enzyme | - |
Purification (Comment) | Organism |
---|---|
recombinant enzyme is partially purified from HEK-293 cells by subcellular fractionation | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast | higher expression level | Homo sapiens | - |
colon | - |
Homo sapiens | - |
colonic adenocarcinoma cell | 2fold increased expression of gene DKFZp586G1517 compared to normal colon tissue | Homo sapiens | - |
erythrocyte | low expression level | Homo sapiens | - |
kidney | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
lung | higher expression level | Homo sapiens | - |
lymphocyte | low expression level | Homo sapiens | - |
ovary | high expression level | Homo sapiens | - |
pancreas | - |
Homo sapiens | - |
prostate | - |
Homo sapiens | - |
skeletal muscle | low expression level | Homo sapiens | - |
small intestine | higher expression level | Homo sapiens | - |
spleen | - |
Homo sapiens | - |
stomach | - |
Homo sapiens | - |
thymus | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme may participate in the progression of colorectal cancer by conferring growth advantage | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
C1-tetrahydrofolate synthetase | - |
Homo sapiens |
C1-THFS | - |
Homo sapiens |