Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.3.4.21 extracted from

  • Marletta, A.S.; Massarotti, A.; Orsomando, G.; Magni, G.; Rizzi, M.; Garavaglia, S.
    Crystal structure of human nicotinic acid phosphoribosyltransferase (2015), FEBS open bio, 5, 419-428 .
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
by molecular replacement at a resolution of 2.9 A, in its ligand-free form. The enzyme consists of two domains and functions as a dimer with the active site located at the interface of the monomers. NaPRTase acks a tunnel that, in nicotinamide phosphoribosyltransferase EC 2.4.2.12, represents the binding site of inhibitor FK866 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibitory: FK866. NaPRTase acks a tunnel that, in nicotinamide phosphoribosiltransferase EC 2.4.2.12, represents the binding site of inhibitor FK866 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6XQN6
-
-

Subunits

Subunits Comment Organism
? x * 58000, calculated Homo sapiens

Synonyms

Synonyms Comment Organism
NAPRT
-
Homo sapiens
NAPRTase
-
Homo sapiens