Literature summary for 6.3.4.2 extracted from

Huang, Y.; Wang, J.J.; Ghosh, S.; Liu, J.L.
Critical roles of CTP synthase N-terminal in cytoophidium assembly (2017), Exp. Cell Res., 354, 122-133 .

Search for more literature for 6.3.4.2

Protein Variants

Protein Variants	Comment	Organism
A20R	mutation disrupts cytoophidium assembly	Drosophila melanogaster
DELTA20	deletion of the N-terminal 20 amino acids alone is sufficient to disrupt cytoophidium assembly, mutant protein forms distinct cytoplasmic structures which appear as large clusters	Drosophila melanogaster
K2E	mutation disrupts cytoophidium assembly	Drosophila melanogaster
additional information	in cytoophidium assembly, formation of heteromeric CTP synthase filaments takes place, which is disrupted by CTP synthase carrying a mutated N-terminal alanine residue. N-terminal swapping, i.e. exchange of the 20 N-terminal amino acids to the residues of human and yeast CTP synthase does not affect CTPsyn cytoophidium assembly	Drosophila melanogaster
Y3E	mutation disrupts cytoophidium assembly	Drosophila melanogaster

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoophidium	in cytoophidium assembly, formation of heteromeric CTP synthase filaments takes place, which is disrupted by CTP synthase carrying a mutated N-terminal alanine residue	Drosophila melanogaster	97268	-

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	X2JCY2	-	-

Synonyms

Synonyms	Comment	Organism
CTPsyn	-	Drosophila melanogaster

General Information

General Information	Comment	Organism
physiological function	in cytoophidium assembly, formation of heteromeric CTP synthase filaments takes place, which is disrupted by CTP synthase carrying a mutated N-terminal alanine residue	Drosophila melanogaster

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Release 2023.1 (January 2023)