Activating Compound | Comment | Organism | Structure |
---|---|---|---|
GTP | - |
Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of wild-type and mutant enzymes in HEK-293 cells, co-expression with GST-tagged Xenopus laevis peptidyl prolyl isomerase Pin1 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
S575A | site-directed mutagenesis the mutant does not interact with peptidyl prolyl isomerase Pin1 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cyclopentenyl cytosine | a highly specific inhibitor of CTPS1, in vivo inhibition leads to alterations in the cell nuclei and microtubule network, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microtubule | - |
Homo sapiens | 5874 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + UTP + NH3 | Homo sapiens | CTPS1 is involved in microtubule network formation and/or stabilzation, overview | ADP + phosphate + CTP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + UTP + NH3 | - |
Homo sapiens | ADP + phosphate + CTP | - |
? | |
ATP + UTP + NH3 | CTPS1 is involved in microtubule network formation and/or stabilzation, overview | Homo sapiens | ADP + phosphate + CTP | - |
? | |
additional information | CTPS1 interacts with the GST-tagged peptidyl prolyl isomerase Pin1 from Xenopus laevis in a Ser575 phosphorylation-dependent manner, the CTPS1 also binds several other enzyme, e.g. alpha-tubulin, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CTP synthetase 1 | - |
Homo sapiens |
CTPS1 | - |
Homo sapiens |
cytidine triphosphate synthetase 1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |