Literature summary for 6.3.4.2 extracted from

Yang, W.L.; McDonough, V.M.; Ozier-Kalogeropoulos, O.; Adeline, M.T.; Flocco, M.T.; Carman, G.M.
Purification and characterization of CTP synthetase, the product of the URA7 gene in Saccharomyces cerevisiae (1994), Biochemistry, 33, 10785-10793.

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Activating Compound

Activating Compound	Comment	Organism	Structure
2-mercaptoethanol	stimulates	Saccharomyces cerevisiae

Inhibitors

Inhibitors	Comment	Organism	Structure
CTP	allosteric inhibition	Saccharomyces cerevisiae
HgCl2	-	Saccharomyces cerevisiae
NEM	-	Saccharomyces cerevisiae
p-chloromercuribenzenesulfonic acid	-	Saccharomyces cerevisiae

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	dependent on 4 mM Mg2+ for maximal activity	Saccharomyces cerevisiae

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
68000	-	4 * 68000, SDS-PAGE	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Saccharomyces cerevisiae

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
2.51	-	-	Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + UTP + NH4+	-	Saccharomyces cerevisiae	ADP + phosphate + CTP	-	?

Subunits

Subunits	Comment	Organism
More	CTP synthetase oligomerizes to a tetramer in the presence of its substrates UTP and ATP	Saccharomyces cerevisiae
tetramer	4 * 68000, SDS-PAGE	Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)