Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.3.4.2 extracted from

  • Hofer, A.; Steverding, D.; Chabes, A.; Brun, R.; Thelander, L.
    Trypanosoma brucei CTP synthetase: a target for the treatment of African sleeping sickness (2001), Proc. Natl. Acad. Sci. USA, 98, 6412-6416.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.3.4.2

Application

Application Comment Organism
medicine the enzyme is an target for treatment of African sleeping sickness because the trypanosomes, unlike mammalian cells, cannot compensate for the inhibition of CTP synthetase by the salvage of cytidine. The CTP synthetase inhibitors 6-diazo-5-oxo-L-norleucine and alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid reduce the parasite CTP level even further and inhibit trypanosome proliferation in vitro and in Trypanosoma brucei-infected mice Trypanosoma brucei

Inhibitors

Inhibitors Comment Organism Structure
6-diazo-5-oxo-L-norleucine reduces the parasite CTP level even further and inhibits trypanosome proliferation in vitro and in Trypanosoma brucei-infected mice Trypanosoma brucei
alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid reduces the parasite CTP level even further and inhibits trypanosome proliferation in vitro and in Trypanosoma brucei-infected mice Trypanosoma brucei

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + UTP + NH4+
-
 Trypanosoma brucei ADP + phosphate + CTP
-
 ?