Literature summary for 6.3.4.2 extracted from

Verschuur, A.C.; Van Gennip, A.H.; Leen, R.; Meinsma, R.; Voute, P.A.; van Kuilenburg, A.B.
In vitro inhibition of cytidine triphosphate synthetase activity by cyclopentenyl cytosine in paediatric acute lymphocytic leukaemia (2000), Br. J. Haematol., 110, 161-169.

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Inhibitors

Inhibitors	Comment	Organism	Structure
cyclopentenyl cytosine	the inhibitor has a cytostatic effect on lymphoblasts of children with acute lymphocytic leukemia	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	key enzyme for biosynthesis of cytosine ribonucleotides	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
leukemia cell	significantly higher activity is detected in leukaemic cells of children suffering from acute lymphocytic leukemia than in lymphocytes of healthy controls	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + UTP + NH4+	-	Homo sapiens	ADP + phosphate + CTP	-	?
additional information	key enzyme for biosynthesis of cytosine ribonucleotides	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)