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Literature summary for 6.3.4.16 extracted from

  • Ogura, M.; Nakamura, Y.; Tanaka, D.; Zhuang, X.; Fujita, Y.; Obara, A.; Hamasaki, A.; Hosokawa, M.; Inagaki, N.
    Overexpression of SIRT5 confirms its involvement in deacetylation and activation of carbamoyl phosphate synthetase 1 (2010), Biochem. Biophys. Res. Commun., 393, 73-78.
    View publication on PubMed
Search for more literature for 6.3.4.16

Activating Compound

Activating Compound Comment Organism Structure
SIRT5 an NAD-dependent SIR2 deacetylase homologue, is involved in deacetylation and activation of carbamoyl phosphate synthetase 1, overview Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information overexpression of SIRT5 in mice leads to increased deacetylation and activation of CPS1 protein in liver of transgenic mice compared to wild-type mice. Urea production is upregulated in hepatocytes of SIRT5 transgenic mice Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 ATP + NH3 + CO2 + H2O Mus musculus
-
 2 ADP + phosphate + carbamoyl phosphate
-
 ?
2 ATP + NH3 + CO2 + H2O Mus musculus C57BL/6
-
 2 ADP + phosphate + carbamoyl phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6 mice
-
Mus musculus C57BL/6
-
 C57BL/6 mice
-

Posttranslational Modification

Posttranslational Modification Comment Organism
acetylation mitochondrial CPSI is acetylated, and activated by deacetylation through SIRT5, overview Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ATP + NH3 + CO2 + H2O
-
 Mus musculus 2 ADP + phosphate + carbamoyl phosphate
-
 ?
2 ATP + NH3 + CO2 + H2O
-
 Mus musculus C57BL/6 2 ADP + phosphate + carbamoyl phosphate
-
 ?

Synonyms

Synonyms Comment Organism
carbamoyl phosphate synthetase 1
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

General Information

General Information Comment Organism
metabolism CPS1 is a key enzyme of the urea cycle that catalyzes condensation of ammonia with bicarbonate to form carbamoyl phosphate Mus musculus