Crystallization (Comment) | Organism |
---|---|
1.5 A resolution structure of recombinant enzyme | Pyrococcus furiosus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + NH3 + CO2 + H2O | Pyrococcus furiosus | the product carbamoyl phosphate is used in the biosynthesis of pyrimidines, arginine, and urea | ADP + phosphate + carbamoylphosphate | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pyrococcus furiosus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
2 ATP + NH3 + hydrogencarbonate = 2 ADP + phosphate + carbamoyl phosphate | the enzyme structure is ill-suited for catalysing the characteristic three-step reaction of carbamoyl-phosphate synthetase and supports the view that the carbamate kinase-like carbamoyl-phosphate synthetase is in fact a highly thermostable and very slow carbamate kinase that, in extreme environment of Pyrococcus furiosus, may have the new function of making, rather than using, carbamoyl phosphate | Pyrococcus furiosus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + carbamate | - |
Pyrococcus furiosus | ADP + carbamoyl phosphate | - |
r | |
ATP + NH3 + CO2 + H2O | three step reaction | Pyrococcus furiosus | ADP + phosphate + carbamoyl phosphate | - |
ir | |
ATP + NH3 + CO2 + H2O | the product carbamoyl phosphate is used in the biosynthesis of pyrimidines, arginine, and urea | Pyrococcus furiosus | ADP + phosphate + carbamoylphosphate | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
carbamate kinase-like carbamoyl-phosphate synthetase | - |
Pyrococcus furiosus |
CK-like CPS | - |
Pyrococcus furiosus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
additional information | - |
the enzyme is extreme thermostable | Pyrococcus furiosus |