Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.3.4.16 extracted from

  • Rubio, V.; Ramponi, G.; Grisolia, S.
    Carbamoyl phosphate synthetase I of human liver. Purification, some properties and immunological cross-reactivity with the rat liver enzyme (1981), Biochim. Biophys. Acta, 659, 150-160.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
acetylglutamate activates Homo sapiens
acetylglutamate Km: 0.15 mM Homo sapiens
N-carbamoylglutamate effective activator, Km: 2.0 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.26
-
ATP
-
Homo sapiens
1.3
-
NH4+
-
Homo sapiens
2.2
-
ATP HCO3- Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
160000
-
1 * 160000, SDS-PAGE in presence of a reducing agent Homo sapiens
165000 178000 gel filtration, density gradient centrifugation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.5
-
-
Homo sapiens

Storage Stability

Storage Stability Organism
4°C, stable for at least 1 month Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ATP + NH4+ + HCO3- ATP in form of CoATP2- Homo sapiens 2 ADP + phosphate + carbamoyl phosphate
-
?
ATP + NH4+ + CO2 + H2O no activity with Gln Homo sapiens ADP + phosphate + carbamoylphosphate
-
?

Subunits

Subunits Comment Organism
monomer 1 * 160000, SDS-PAGE in presence of a reducing agent Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
37
-
4 h, 30% loss of activity Homo sapiens
46
-
5 min, 25% loss of activity Homo sapiens
55
-
5 min, 80% loss of activity Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
additional information
-
Homo sapiens