Activating Compound | Comment | Organism | Structure |
---|---|---|---|
acetylglutamate | activates | Rattus norvegicus | |
acetylglutamate | binding of acetylglutamate to carbamoylphosphate synthetase requires the presence of both Mg2+ and MgATP2-. The binding is inhibited by Ca2+ and N-carbamoylglutamate | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | binding of acetylglutamate to carbamoylphosphate synthetase is inhibited | Rattus norvegicus | |
Carbamoyl phosphate | 50% inhibition at 13 mM | Rattus norvegicus | |
N-carbamoylglutamate | binding of acetylglutamate to carbamoylphosphate synthetase is inhibited | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.7 | - |
NH3 | - |
Rattus norvegicus | |
1.2 | - |
ATP | - |
Rattus norvegicus | |
2 | - |
NH4+ | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 ATP + NH3 + CO2 + H2O | Rattus norvegicus | first enzyme involved in the biosynthesis of urea in the liver ureotelic animals | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 ATP + NH3 + CO2 + H2O | first enzyme involved in the biosynthesis of urea in the liver ureotelic animals | Rattus norvegicus | ? | - |
? | |
2 ATP + NH4+ + HCO3- | ATP in form of MgATP2- | Rattus norvegicus | 2 ADP + phosphate + carbamoyl phosphate | - |
? | |
ATP + NH4+ + CO2 + H2O | - |
Rattus norvegicus | ADP + phosphate + carbamoylphosphate | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
13 | - |
Carbamoyl phosphate | - |
Rattus norvegicus |