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Literature summary for 6.3.4.15 extracted from

  • Paparella, A.; Feng, J.; Blanco-Rodriguez, B.; Feng, Z.; Phetsang, W.; Blaskovich, M.; Cooper, M.; Booker, G.; Polyak, S.; Abell, A.
    A template guided approach to generating cell permeable inhibitors of Staphylococcus aureus biotin protein ligase (2017), Tetrahedron, 74, 1175-1183 .
No PubMed abstract available
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Application

Application Comment Organism
analysis fluorescent probe (4S)-4-[5-(1-[3-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]propyl]-1H-1,2,3-triazol-4-yl)pentyl]tetrahydro-1H-thieno[3,4-d]imidazol-2(3H)-one is synthesized by Bpl in vivo, accumulates in cytoplasm and can be used to gain insights into the mechanism of uptake, efflux and metabolism of BPL inhibitors Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(4S)-4-(hept-6-yn-1-yl)tetrahydro-1H-thieno[3,4-d]imidazol-2(3H)-one + 9-(4-azidobutyl)-9H-purin-6-amine i.e. reaction of acetylene derivative of biotin and an azide-functionalized adenine Staphylococcus aureus (4S)-4-(5-[1-[4-(6-amino-9H-purin-9-yl)butyl]-1H-1,2,3-triazol-4-yl]pentyl)tetrahydro-1H-thieno[3,4-d]imidazol-2(3H)-one
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 ?
(4S)-4-(hept-6-yn-1-yl)tetrahydro-1H-thieno[3,4-d]imidazol-2(3H)-one + N-(3-azidopropyl)-7-nitro-2,1,3-benzoxadiazol-4-amine i.e. reaction of acetylene derivative of biotin and an azide-functionalied analogue of the fluorophore nitrobenzofurazan Staphylococcus aureus (4S)-4-[5-(1-[3-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]propyl]-1H-1,2,3-triazol-4-yl)pentyl]tetrahydro-1H-thieno[3,4-d]imidazol-2(3H)-one
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 ?