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Literature summary for 6.3.4.15 extracted from

  • Bockman, M.R.; Kalinda, A.S.; Petrelli, R.; De la Mora-Rey, T.; Tiwari, D.; Liu, F.; Dawadi, S.; Nandakumar, M.; Rhee, K.Y.; Schnappinger, D.; Finzel, B.C.; Aldrich, C.C.
    Targeting Mycobacterium tuberculosis biotin protein ligase (MtBPL) with nucleoside-based bisubstrate adenylation inhibitors (2015), J. Med. Chem., 58, 7349-7369 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
(2'R,6'S)-9-[6'-([[N-(D-biotinoyl)sulfamoyl]oxy]methyl)morpholin-2'-yl]adenine nucleoside-based inhibitor, KD value 0.324 nM Mycobacterium tuberculosis
2'-amino-5'-[N-(D-biotinoyl)sulfamoyl]amino-3',5'-dideoxyadenosine nucleoside-based inhibitor, KD value 0.627 nM Mycobacterium tuberculosis
9-[2'-azido-5'-O-[N-(D-biotinoyl)sulfamoyl]-2'-deoxy-beta-D-arabinofuranosyl]adenine nucleoside-based inhibitor, KD value 0.027 nM. Strongest binding inhibitor in series Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis I6YFP0
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Mycobacterium tuberculosis H37Rv I6YFP0
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