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Literature summary for 6.3.4.15 extracted from

  • Wang, Z.; Moslehi-Jenabian, S.; Solem, C.; Jensen, P.
    Increased expression of pyruvate carboxylase and biotin protein ligase increases lysine production in a biotin prototrophic Corynebacterium glutamicum strain (2015), Eng. Life Sci., 15, 73-82 .
No PubMed abstract available

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
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Bacillus subtilis 168
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Synonyms

Synonyms Comment Organism
BirA
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Bacillus subtilis

General Information

General Information Comment Organism
physiological function expression of biotin operon genes bioW, bioA, bioF, bioD, bioB, and bioI in Corynebacterium glutamicum. The recombinant strain is able to produce lysine in a medium lacking biotin, and the lysine yield on glucose is similar to what is obtained when using a medium containing biotin. Specific growth rate decreases by of 20% when the strain is cultivated without biotin. Neither pyruvate carboxylase pycA nor biotin ligase birA overexpression, whether alone or in combination, has an effect on specific growth rate Bacillus subtilis