Literature summary for 6.3.4.10 extracted from

Bao, B.; Wijeratne, S.S.; Rodriguez-Melendez, R.; Zempleni, J.
Human holocarboxylase synthetase with a start site at methionine-58 is the predominant nuclear variant of this protein and has catalytic activity (2011), Biochem. Biophys. Res. Commun., 412, 115-120.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in HEK-293 cells	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	localizes predominantly in the cytoplasm	Homo sapiens	5737	-
nucleus	-	Homo sapiens	5634	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
115000	-	N-terminal glutathione S transferase-tagged enzyme, x * 115000, SDS-PAGE	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]	Homo sapiens	-	AMP + diphosphate + [propionyl-CoA:carbon-dioxide ligase (ADP-forming)]	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)]	-	Homo sapiens	AMP + diphosphate + [propionyl-CoA:carbon-dioxide ligase (ADP-forming)]	-	?

Subunits

Subunits	Comment	Organism
?	N-terminal glutathione S transferase-tagged enzyme, x * 115000, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
HLCS	-	Homo sapiens
Holocarboxylase synthetase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)