Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + biotin + apo-[propionyl-CoA carboxylase] | Homo sapiens | - |
AMP + diphosphate + propionyl-CoA carboxylase | - |
? | |
ATP + biotin + histone H4 | Homo sapiens | biotinylation at Lys12 especially in telomeric repeats, overview | AMP + diphosphate + biotin-histone H4 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Homo sapiens | - |
IMR-90 cell | lung fibroblasts, quantitative determination of HCS in wild-type IMR-90 fibroblasts and in those recombinantly overexpressing human telomerase, evaluation as a cell model for investigation of HCS in epigenetic regulation, histone biotinylation in aging cells, overview | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + biotin + apo-[propionyl-CoA carboxylase] | - |
Homo sapiens | AMP + diphosphate + propionyl-CoA carboxylase | - |
? | |
ATP + biotin + histone H4 | biotinylation at Lys12 especially in telomeric repeats, overview | Homo sapiens | AMP + diphosphate + biotin-histone H4 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HCS | - |
Homo sapiens |
Holocarboxylase synthetase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | biotinylation of lysine residues in histones by holocarboxylase synthetase is an epigenetic diet-dependent mechanism to regulate chromatin structure and gene expression | Homo sapiens |