Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
mitochondria | - |
Homo sapiens | - |
- |
mitochondrion | - |
Homo sapiens | 5739 | - |
additional information | isozyme subcellular localization, immunofluorescence study, overview | Homo sapiens | - |
- |
nucleus | the longer Met58 isoform | Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + biotin + apo-[propionyl CoA carboxylase] | Homo sapiens | - |
AMP + diphosphate + propionyl CoA carboxylase | - |
? | |
additional information | Homo sapiens | although mammals have multiple biotin-dependent enzymes there is only a single gene encoding holocarboxylase synthetase, HCS, responsible for all cellular biotinylation. The enzyme catalyzes the reactions of EC 6.3.4.10, EC 6.3.4.11, and EC 6.3.4.15, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
three isozymes that differ at the N-terminus | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293T cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
T-lymphocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + biotin + apo-[propionyl CoA carboxylase] | - |
Homo sapiens | AMP + diphosphate + propionyl CoA carboxylase | - |
? | |
additional information | although mammals have multiple biotin-dependent enzymes there is only a single gene encoding holocarboxylase synthetase, HCS, responsible for all cellular biotinylation. The enzyme catalyzes the reactions of EC 6.3.4.10, EC 6.3.4.11, and EC 6.3.4.15, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HCS | - |
Homo sapiens |
Holocarboxylase synthetase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | holocarboxylase synthetase governs the cellular fate of the essential micronutrient biotin, i.e. vitamin H or B7 | Homo sapiens |
physiological function | HCS is responsible for attaching biotin onto the biotin-dependent enzymes that reside in the cytoplasm and mitochondria | Homo sapiens |