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Literature summary for 6.3.4.10 extracted from

  • Chiba, Y.; Suzuki, Y.; Aoki, Y.; Ishida, Y.; Narisawa, K.
    Purification and properties of bovine liver holocarboxylase synthetase (1994), Arch. Biochem. Biophys., 313, 8-14.
    View publication on PubMed
Search for more literature for 6.3.4.10

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000013
-
 biotin
-
 Bos taurus
0.02
-
 ATP
-
 Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Bos taurus 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
 gel filtration Bos taurus
64000
-
 1 * 64000, SDS-PAGE Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.514
-
-
 Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] biotinylates apopropionyl-CoA carboxylase from patients with holocarboxylase synthetase deficiency Bos taurus AMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
 ?
CTP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] 117% of the activity relative to ATP Bos taurus CMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
 ?
GTP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] 46% of the activity relative to ATP Bos taurus GMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
 ?
ITP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] 47% of the activity relative to ATP Bos taurus IMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 64000, SDS-PAGE Bos taurus