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Literature summary for 6.3.3.2 extracted from

  • Field, M.S.; Szebenyi, D.M.; Perry, C.A.; Stover, P.J.
    Inhibition of 5,10-methenyltetrahydrofolate synthetase (2007), Arch. Biochem. Biophys., 458, 194-201.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
Y151 able to use 5-formyltetrahydrohomofolate as a substrate Mus musculus
Y152A increased turnover rate compared to the wild type enzyme Mus musculus
Y152F decreased turnover rate compared to the wild type enzyme Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
5-formyl,10-methyltetrahydrofolate weak inhibitor Mus musculus
5-Formyltetrahydrohomofolate effective inhibitor Mus musculus
N-(4-{[2-(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)ethyl](methyl)amino}benzoyl)-L-glutamic acid at 37°C in 100 mM MES, pH 6.0 Mus musculus
[6R,S]-5-formyl,10-methyltetrahydrofolateGlu3
-
Mus musculus
[6R,S]-5-formyl,11-methyltetrahydrohomofolate
-
Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.009
-
5-formyltetrahydrofolate mutant enzyme Y151A, in 100 mM MES, pH 6.0, at 37°C Mus musculus
0.01
-
5-formyltetrahydrofolate wild type enzyme, in 100 mM MES, pH 6.0, at 37°C Mus musculus
0.047
-
5-formyltetrahydrofolate mutant enzyme Y152F, in 100 mM MES, pH 6.0, at 37°C Mus musculus
3
-
5-formyltetrahydrofolate mutant enzyme Y152A, in 100 mM MES, pH 6.0, at 37°C Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ dependent Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5-formyltetrahydrofolate
-
Mus musculus ADP + 5,10-methenyltetrahydrofolate + phosphate
-
ir
additional information 5-formyltetrahydrohomofolate, 10-formyltetrahydrohomofolate, and 5-formyl,10-methyltetrahydrofolate are no substrates Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
5,10-Methenyltetrahydrofolate synthetase
-
Mus musculus
Methenyltetrahydrofolate synthetase
-
Mus musculus
MTHFS
-
Mus musculus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.02
-
5-formyltetrahydrofolate mutant enzyme Y152A, in 100 mM MES, pH 6.0, at 37°C Mus musculus
0.92
-
5-formyltetrahydrofolate mutant enzyme Y151A, in 100 mM MES, pH 6.0, at 37°C Mus musculus
3.33
-
5-formyltetrahydrofolate wild type enzyme, in 100 mM MES, pH 6.0, at 37°C Mus musculus
4.3
-
5-formyltetrahydrofolate mutant enzyme Y152F, in 100 mM MES, pH 6.0, at 37°C Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0007
-
5-Formyltetrahydrohomofolate at 37°C in 100 mM MES, pH 6.0 Mus musculus
0.001
-
5-formyl,10-methyltetrahydrofolate at 37°C in 100 mM MES, pH 6.0 Mus musculus
0.006
-
[6R,S]-5-formyl,11-methyltetrahydrohomofolate at 37°C in 100 mM MES, pH 6.0 Mus musculus
0.02
-
[6R,S]-5-formyl,10-methyltetrahydrofolateGlu3 at 37°C in 100 mM MES, pH 6.0 Mus musculus