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Literature summary for 6.3.3.1 extracted from

  • Schrimsher, J.L.; Schendel, F.J.; Stubbe, J.; Smith, J.M.
    Purification and characterization of aminoimidazole ribonucleotide synthetase from Escherichia coli (1986), Biochemistry, 25, 4366-4371.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-(5-phosphoribosyl)-5-aminoimidazole
-
Escherichia coli
ADP
-
Escherichia coli
phosphate
-
Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.027
-
2-(formamido)-N1-(5-phosphoribosyl)acetamidine
-
Escherichia coli
0.065
-
ATP
-
Escherichia coli
0.172
-
ATPgammaS
-
Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
K+ absolutely required Escherichia coli
K+ Km: 96 mM Escherichia coli
Mg2+ absolutely required Escherichia coli
Mg2+ Km: 0.3 mM Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
38500
-
2 * 38500, SDS-PAGE Escherichia coli
71700
-
gel filtration, sucrose density gradient ultracentrifugation Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 2-(formamido)-N1-(5-phosphoribosyl)acetamidine Escherichia coli fifth step in de novo purine biosynthesis ?
-
?
ATP + 2-(formamido)-N1-(5-phosphoribosyl)acetamidine Escherichia coli enzyme of purine biosynthetic pathway ?
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli

Reaction

Reaction Comment Organism Reaction ID
ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole enzyme catalyzes transfer of the oxygen of the formyl group to phosphate Escherichia coli
ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole sequential mechanism in which ATP binds first to the enzyme and ADP is released last Escherichia coli

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.35
-
-
Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine ATP in form of MgATP2- Escherichia coli ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole
-
?
ATP + 2-(formamido)-N1-(5-phosphoribosyl)acetamidine
-
Escherichia coli ADP + phosphate + 1-(5-phosphoribosyl)-5-aminoimidazole
-
?
ATP + 2-(formamido)-N1-(5-phosphoribosyl)acetamidine fifth step in de novo purine biosynthesis Escherichia coli ?
-
?
ATP + 2-(formamido)-N1-(5-phosphoribosyl)acetamidine enzyme of purine biosynthetic pathway Escherichia coli ?
-
?
ATPgammaS + 2-(formamido)-N1-(5-phosphoribosyl)acetamidine
-
Escherichia coli ADP + ? + 1-(5-phosphoribosyl)-5-aminoimidazole
-
?

Subunits

Subunits Comment Organism
dimer 2 * 38500, SDS-PAGE Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
-
Escherichia coli