Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(5-phosphoribosyl)-5-aminoimidazole | - |
Escherichia coli | |
ADP | - |
Escherichia coli | |
phosphate | - |
Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.027 | - |
2-(formamido)-N1-(5-phosphoribosyl)acetamidine | - |
Escherichia coli | |
0.065 | - |
ATP | - |
Escherichia coli | |
0.172 | - |
ATPgammaS | - |
Escherichia coli |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
K+ | absolutely required | Escherichia coli | |
K+ | Km: 96 mM | Escherichia coli | |
Mg2+ | absolutely required | Escherichia coli | |
Mg2+ | Km: 0.3 mM | Escherichia coli |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
38500 | - |
2 * 38500, SDS-PAGE | Escherichia coli |
71700 | - |
gel filtration, sucrose density gradient ultracentrifugation | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 2-(formamido)-N1-(5-phosphoribosyl)acetamidine | Escherichia coli | fifth step in de novo purine biosynthesis | ? | - |
? | |
ATP + 2-(formamido)-N1-(5-phosphoribosyl)acetamidine | Escherichia coli | enzyme of purine biosynthetic pathway | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Escherichia coli |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole | enzyme catalyzes transfer of the oxygen of the formyl group to phosphate | Escherichia coli | |
ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole | sequential mechanism in which ATP binds first to the enzyme and ADP is released last | Escherichia coli |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
3.35 | - |
- |
Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine | ATP in form of MgATP2- | Escherichia coli | ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole | - |
? | |
ATP + 2-(formamido)-N1-(5-phosphoribosyl)acetamidine | - |
Escherichia coli | ADP + phosphate + 1-(5-phosphoribosyl)-5-aminoimidazole | - |
? | |
ATP + 2-(formamido)-N1-(5-phosphoribosyl)acetamidine | fifth step in de novo purine biosynthesis | Escherichia coli | ? | - |
? | |
ATP + 2-(formamido)-N1-(5-phosphoribosyl)acetamidine | enzyme of purine biosynthetic pathway | Escherichia coli | ? | - |
? | |
ATPgammaS + 2-(formamido)-N1-(5-phosphoribosyl)acetamidine | - |
Escherichia coli | ADP + ? + 1-(5-phosphoribosyl)-5-aminoimidazole | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 38500, SDS-PAGE | Escherichia coli |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.8 | - |
- |
Escherichia coli |