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Literature summary for 6.3.2.9 extracted from

  • Paradis-Bleau, C.; Beaumont, M.; Boudreault, L.; Lloyd, A.; Sanschagrin, F.; Bugg, T.D.; Levesque, R.C.
    Selection of peptide inhibitors against the Pseudomonas aeruginosa MurD cell wall enzyme (2006), Peptides, 27, 1693-1700.
    View publication on PubMed
Search for more literature for 6.3.2.9

Inhibitors

Inhibitors Comment Organism Structure
HLPTSSLFDTTG
-
 Pseudomonas aeruginosa
RPTHSPI peptides are synthesized from consensus sequences to evaluate their inhibitory potential against the essential MurD enzyme. The C-7-C mers MurDp1 (RPTHSPI) gives a decrease of MurD ATPase activity with a significant IC50 value of 4 mM. The 12 mers MurDp2 (HLPTSSLFDTTG) inhibits MurD with an IC50 value of 15 mM indicating a weak inhibition. Both peptides show a correlation between an increase in concentration versus an increase in inhibition values Pseudomonas aeruginosa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
51000
-
 x * 51000, SDS-PAGE Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
-
-

Subunits

Subunits Comment Organism
? x * 51000, SDS-PAGE Pseudomonas aeruginosa

Synonyms

Synonyms Comment Organism
MurD cell wall enzyme
-
 Pseudomonas aeruginosa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4
-
 RPTHSPI
-
 Pseudomonas aeruginosa
15
-
 HLPTSSLFDTTG
-
 Pseudomonas aeruginosa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
 peptides are synthesized from consensus sequences to evaluate their inhibitory potential against the essential MurD enzyme. The C-7-C mers MurDp1 gives a decrease of MurD ATPase activity with a significant IC50 value of 4 mM. The 12 mers MurDp2 inhibits MurD with an IC50 value of 15 mM Pseudomonas aeruginosa additional information
15
-
 peptides are synthesized from consensus sequences to evaluate their inhibitory potential against the essential MurD enzyme. The C-7-C mers MurDp1 (RPTHSPI) gives a decrease of MurD ATPase activity with a significant IC50 value of 4 mM. The 12 mers MurDp2 Pseudomonas aeruginosa RPTHSPI