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Literature summary for 6.3.2.62 extracted from

  • van Dijk, J.; Rogowski, K.; Miro, J.; Lacroix, B.; Edde, B.; Janke, C.
    A targeted multienzyme mechanism for selective microtubule polyglutamylation (2007), Mol. Cell, 26, 437-448 .
    View publication on PubMed
Search for more literature for 6.3.2.62

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in HeLa cells Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus A4Q9F0
-
-
Mus musculus Q80UG8
-
-
Tetrahymena thermophila Q23MT7
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [alpha-tubulin]-L-glutamate + L-glutamate high initiating activity, no elongation activity. The enzyme modifies both alpha- and beta-tubulin and shows a preference towards beta-tubulin Mus musculus [alpha-tubulin]-(gamma-L-glutamyl)-L-glutamate + ADP + phosphate
-
 ?
ATP + [beta-tubulin]-L-glutamate + L-glutamate high initiating activity, no elongation activity. The enzyme modifies both alpha- and beta-tubulin and shows a preference towards beta-tubulin Mus musculus [beta-tubulin]-(gamma-L-glutamyl)-L-glutamate + ADP + phosphate
-
 ?
n ATP + [alpha-tubulin]-(alpha-L-glutamyl-gamma-L-glutamyl)-L-glutamate + n L-glutamate no initiating activity, high elongation activity. The enzyme modifies both alpha- and beta-tubulin and shows a preference towards beta-tubulin Tetrahymena thermophila [alpha-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
n ATP + [alpha-tubulin]-L-glutamate + n L-glutamate high initiating activity, low elongation activity. The enzyme modifies both alpha- and beta-tubulin and shows a preference towards beta-tubulin Mus musculus [alpha-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
n ATP + [beta-tubulin]-(alpha-L-glutamyl-gamma-L-glutamyl)-L-glutamate + n L-glutamate no initiating activity, high elongation activity. The enzyme modifies both alpha- and beta-tubulin and shows a preference towards beta-tubulin Tetrahymena thermophila [beta-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?
n ATP + [beta-tubulin]-L-glutamate + n L-glutamate high initiating activity, low elongation activity. The enzyme modifies both alpha- and beta-tubulin and shows a preference towards beta-tubulin Mus musculus [beta-tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?

Synonyms

Synonyms Comment Organism
elongating polyglutamylase
-
 Tetrahymena thermophila
TTLL4
-
 Mus musculus
TTLL7
-
 Mus musculus
TtTtll6Ap
-
 Tetrahymena thermophila