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Literature summary for 6.3.2.61 extracted from

  • Van Dijk, J.; Miro, J.; Strub, J.; Lacroix, B.; Van Dorsselaer, A.; Edde, B.; Janke, C.
    Polyglutamylation is a post-translational modification with a broad range of substrates (2008), J. Biol. Chem., 283, 3915-3922 .
    View publication on PubMed
Search for more literature for 6.3.2.61

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 2.4 mM used in assay conditions Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
n ATP + [tubulin]-L-glutamate + n L-glutamate Homo sapiens overall reaction [tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q14679
-
-
Homo sapiens Q6EMB2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acidic nuclear phosphoprotein 32 family, member A + L-glutamate low activity with isoform TTLL5 Homo sapiens ?
-
 ?
ATP + acidic nuclear phosphoprotein 32 family, member A + L-glutamate very low activity with isoform TTLL4 Homo sapiens ?
-
 ?
ATP + acidic nuclear phosphoprotein 32 family, member B + L-glutamate high activity with isoform TTLL4 Homo sapiens ?
-
 ?
ATP + acidic nuclear phosphoprotein 32 family, member B + L-glutamate low activity with isoform TTLL5 Homo sapiens ?
-
 ?
ATP + B23 nucleophosmin + L-glutamate highest activity with isoform TTLL4 Homo sapiens ?
-
 ?
ATP + B23 nucleophosmin + L-glutamate low activity with isoform TTLL5 Homo sapiens ?
-
 ?
ATP + EB1 protein + L-glutamate very low activity with isoform TTLL4 Homo sapiens ?
-
 ?
ATP + microtubule + L-glutamate
-
 Homo sapiens ?
-
 ?
ATP + microtubule + L-glutamate highest activity with isoform TTLL5 Homo sapiens ?
-
 ?
ATP + NF45 protein + L-glutamate low activity with isoform TTLL5 Homo sapiens ?
-
 ?
ATP + NF45 protein + L-glutamate very low activity with isoform TTLL4 Homo sapiens ?
-
 ?
ATP + NPN2 protein + L-glutamate high activity with isoform TTLL4 Homo sapiens ?
-
 ?
ATP + NPN3 protein + L-glutamate very low activity with isoform TTLL4 Homo sapiens ?
-
 ?
ATP + nucleosome assembly protein 1-like 1 + L-glutamate
-
 Homo sapiens ?
-
 ?
ATP + nucleosome assembly protein 1-like 1 + L-glutamate low activity with isoform TTLL5 Homo sapiens ?
-
 ?
ATP + nucleosome assembly protein 1-like 4 + L-glutamate
-
 Homo sapiens ?
-
 ?
ATP + nucleosome assembly protein 1-like 4 + L-glutamate high activity with isoform TTLL4 Homo sapiens ?
-
 ?
ATP + protein SET + L-glutamate high activity with isoform TTLL5 Homo sapiens ?
-
 ?
ATP + protein SET + L-glutamate very low activity with isoform TTLL4 Homo sapiens ?
-
 ?
additional information EB3 protein and HMG-B1 are no substrates for isoform TTLL4 Homo sapiens ?
-
-
n ATP + [tubulin]-L-glutamate + n L-glutamate overall reaction Homo sapiens [tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate
-
 ?

Synonyms

Synonyms Comment Organism
TTLL4 main polyglutamylase enzyme present in HeLa cells Homo sapiens
TTLL5
-
 Homo sapiens
tubulin-tyrosine ligase-like protein
-
 Homo sapiens