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Literature summary for 6.3.2.61 extracted from

  • Wloga, D.; Rogowski, K.; Sharma, N.; van Dijk, J.; Janke, C.; Edde, B.; Bre, M.-H.; Levilliers, N.; Redeker, V.; Duan, J.; Gorovsky, M.A.; Jerka-Dziadosz, M.; Gaertig, J.
    Glutamylation on alpha-tubulin is not essential but affects the assembly and functions of a subset of microtubules in Tetrahymena thermophila (2008), Eukaryot. Cell, 7, 1362-1372 .
No PubMed abstract available
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Cloned(Commentary)

Cloned (Comment) Organism
-
 Tetrahymena thermophila

Localization

Localization Comment Organism GeneOntology No. Textmining
cilium Ttll9p is mainly localized in cilia Tetrahymena thermophila 5929
-
flagellar basal body Ttll1p localizes primarily to the basal bodies of oral and somatic cilia Tetrahymena thermophila
-
-

Organism

Organism UniProt Comment Textmining
Tetrahymena thermophila I7MCG4
-
-
Tetrahymena thermophila Q23SI8
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Tetrahymena thermophila
partial Tetrahymena thermophila

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + alpha tubulin + L-glutamate Ttll1p glutamylase preferentially modifies alpha-tubulin. It shows a chain-initiating activity Tetrahymena thermophila ?
-
 ?
ATP + alpha tubulin + L-glutamate Ttll9p glutamylase preferentially modifies alpha-tubulin. It has primarily a chain-elongating activity Tetrahymena thermophila ?
-
 ?
ATP + alpha tubulin + L-glutamate Ttll9p glutamylase preferentially modifies alpha-tubulin. It has primarily a chain-elongating activity Tetrahymena thermophila SB210 ?
-
 ?
ATP + alpha tubulin + L-glutamate Ttll1p glutamylase preferentially modifies alpha-tubulin. It shows a chain-initiating activity Tetrahymena thermophila SB210 ?
-
 ?

Synonyms

Synonyms Comment Organism
Ttll1p
-
 Tetrahymena thermophila
Ttll9p
-
 Tetrahymena thermophila

General Information

General Information Comment Organism
malfunction disruption of the TTLL1 and TTLL9 genes decreases the rates of cell multiplication and phagocytosis. Cells lacking both genes had fewer cortical microtubules and show defects in the maturation of basal bodies Tetrahymena thermophila
malfunction disruption of the TTLL1 and TTLL9 genes decreases the rates of cell multiplication and phagocytosis. Cells lacking both genes have fewer cortical microtubules and show defects in the maturation of basal bodies Tetrahymena thermophila
physiological function glutamylation on alpha-tubulin is not essential but is required for efficiency of assembly and function of a subset of microtubule-based organelles. Furthermore, the spatial restriction of modifying enzymes (TTLL1 and TTLL9) appears to be a major mechanism that drives differential glutamylation at the subcellular level Tetrahymena thermophila
physiological function glutamylation on alpha-tubulin is not essential but is required for efficiency of assembly and function of a subset of microtubule-based organelles. Furthermore, the spatial restriction of modifying enzymes appears to be a major mechanism that drives differential glutamylation at the subcellular level Tetrahymena thermophila