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Literature summary for 6.3.2.6 extracted from
- Molecular dynamics perspective on the protein thermal stability: a case study using SAICAR synthetase (2013), J. Chem. Inf. Model., 53, 2448-2461.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate | Escherichia coli | - |
ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | - |
? |  |
| ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate | Ehrlichia chaffeensis | - |
ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | - |
? | |
| ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate | Geobacillus kaustophilus | - |
ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | - |
? | |
| ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate | Pyrococcus horikoshii | - |
ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | - |
? | |
| ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate | Methanocaldococcus jannaschii | - |
ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | - |
? | |
| ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate | Pyrococcus horikoshii DSM 12428 | - |
ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | - |
? | |
| ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate | Methanocaldococcus jannaschii DSM 2661 | - |
ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ehrlichia chaffeensis | - |
- |
- |
| Escherichia coli | - |
- |
- |
| Geobacillus kaustophilus | - |
- |
- |
| Methanocaldococcus jannaschii | Q58987 | - |
- |
| Methanocaldococcus jannaschii DSM 2661 | Q58987 | - |
- |
| Pyrococcus horikoshii | O57978 | - |
- |
| Pyrococcus horikoshii DSM 12428 | O57978 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate | - |
Escherichia coli | ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | - |
? | |
| ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate | - |
Ehrlichia chaffeensis | ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | - |
? | |
| ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate | - |
Geobacillus kaustophilus | ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | - |
? | |
| ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate | - |
Pyrococcus horikoshii | ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | - |
? | |
| ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate | - |
Methanocaldococcus jannaschii | ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | - |
? | |
| ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate | - |
Pyrococcus horikoshii DSM 12428 | ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | - |
? | |
| ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate | - |
Methanocaldococcus jannaschii DSM 2661 | ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Escherichia coli |
| dimer | - |
Ehrlichia chaffeensis |
| dimer | - |
Geobacillus kaustophilus |
| dimer | - |
Pyrococcus horikoshii |
| dimer | - |
Methanocaldococcus jannaschii |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MjSS | - |
Methanocaldococcus jannaschii |
| PhSS | - |
Pyrococcus horikoshii |
| SAICAR synthetase | - |
Escherichia coli |
| SAICAR synthetase | - |
Ehrlichia chaffeensis |
| SAICAR synthetase | - |
Geobacillus kaustophilus |
| SAICAR synthetase | - |
Pyrococcus horikoshii |
| SAICAR synthetase | - |
Methanocaldococcus jannaschii |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| additional information | - |
27-100°C, structure-thermostability molecular dynamics and simulation using the enzyme crystal structure, modeling, overview | Escherichia coli |
| additional information | - |
27-100°C, structure-thermostability molecular dynamics and simulation using the enzyme crystal structure, modeling, overview | Ehrlichia chaffeensis |
| additional information | - |
27-100°C, structure-thermostability molecular dynamics and simulation using the enzyme crystal structure, modeling, overview | Geobacillus kaustophilus |
| additional information | - |
delineation of the mesophilic (Escherichia coli, Ehrlichia chaffeensis), thermophilic (Geobacillus kaustophilus), and hyperthermophilic (Methanocaldococcus jannaschii, Pyrococcus horikoshii) proteins on the basis of their thermal stability by studying their dynamic aspects at 27°C and 60°C using molecular dynamics | Pyrococcus horikoshii |
| additional information | - |
delineation of the mesophilic (Escherichia coli, Ehrlichia chaffeensis), thermophilic (Geobacillus kaustophilus), and hyperthermophilic (Methanocaldococcus jannaschii, Pyrococcus horikoshii) proteins on the basis of their thermal stability by studying their dynamic aspects at 27°C and 60°C using molecular dynamics | Methanocaldococcus jannaschii |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Escherichia coli | |
| ATP | - |
Ehrlichia chaffeensis | |
| ATP | - |
Geobacillus kaustophilus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| additional information | structure-activity molecular dynamics and simulation using the enzyme crystal structure, modeling, overview | Escherichia coli |
| additional information | structure-activity molecular dynamics and simulation using the enzyme crystal structure, modeling, overview | Ehrlichia chaffeensis |
| additional information | structure-activity molecular dynamics and simulation using the enzyme crystal structure, modeling, overview | Geobacillus kaustophilus |
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