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Literature summary for 6.3.2.6 extracted from

  • Buchanan, J.M.; Lukens, L.N.; Miller, R.W.
    N-(5-Amino-1-ribosyl-4-imidazolylcarbonyl)-L-aspartic acid 5¦-phosphate synthetase (1978), Methods Enzymol., 51, 186-193.
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ can replace Mg2+, maximal activation at 0.04 mM Gallus gallus
Mg2+ at 0.05 mM ADP, Mg2+ saturation is reached at 2-3 mM Gallus gallus
Mn2+ can replace Mg2+, maximal activation at 0.06 mM Gallus gallus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-(5'-phosphoribosyl)-5-amino-4-carboxyimidazole + L-Asp Gallus gallus one of the enzymes of the series involved in the biosynthesis of the purine nucleotides de novo ?
-
?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Gallus gallus
-

Storage Stability

Storage Stability Organism
-20°C, concentrated enzyme, above 1 mg/ml, stable Gallus gallus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-(5'-phosphoribosyl)-5-amino-4-carboxyimidazole + L-Asp r Gallus gallus ADP + phosphate + 1-(5'-phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
-
?
ATP + 1-(5'-phosphoribosyl)-5-amino-4-carboxyimidazole + L-Asp in the reverse reaction phosphate can be replaced by arsenate Gallus gallus ADP + phosphate + 1-(5'-phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
-
?
ATP + 1-(5'-phosphoribosyl)-5-amino-4-carboxyimidazole + L-Asp in the reverse reaction ADP cannot be replaced by any of the other nucleoside diphosphates Gallus gallus ADP + phosphate + 1-(5'-phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
-
?
ATP + 1-(5'-phosphoribosyl)-5-amino-4-carboxyimidazole + L-Asp one of the enzymes of the series involved in the biosynthesis of the purine nucleotides de novo Gallus gallus ?
-
?