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Literature summary for 6.3.2.53 extracted from

  • Paradis-Bleau, C.; Beaumont, M.; Boudreault, L.; Lloyd, A.; Sanschagrin, F.; Bugg, T.D.; Levesque, R.C.
    Selection of peptide inhibitors against the Pseudomonas aeruginosa MurD cell wall enzyme (2006), Peptides, 27, 1693-1700 .
    View publication on PubMed
Search for more literature for 6.3.2.53

Inhibitors

Inhibitors Comment Organism Structure
12 mers MurDp2 peptide
-
 Pseudomonas aeruginosa
C-7-C mers MurDp1 peptide
-
 Pseudomonas aeruginosa

Localization

Localization Comment Organism GeneOntology No. Textmining
cell wall
-
 Pseudomonas aeruginosa 5618
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + L-glutamate Pseudomonas aeruginosa
-
 ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate
-
 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + L-glutamate
-
 Pseudomonas aeruginosa ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate
-
 ?

Subunits

Subunits Comment Organism
? x * 51000, SDS-PAGE Pseudomonas aeruginosa

Synonyms

Synonyms Comment Organism
MurD
-
 Pseudomonas aeruginosa
UDP-N-acetylmuramyl-L-alanine:D-glutamate ligase
-
 Pseudomonas aeruginosa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.004
-
 at pH 8.0 and 37°C Pseudomonas aeruginosa C-7-C mers MurDp1 peptide
15
-
 at pH 8.0 and 37°C Pseudomonas aeruginosa 12 mers MurDp2 peptide