Literature summary for 6.3.2.51 extracted from

Daugherty, M.; Polanuyer, B.; Farrell, M.; Scholle, M.; Lykidis, A.; de Crecy-Lagard, V.; Osterman, A.
Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics (2002), J. Biol. Chem., 277, 21431-21439.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21 cells	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + (R)-4'-phosphopantothenate + L-cysteine	Homo sapiens	-	AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine	-	?
CTP + (R)-4'-phosphopantothenate + L-cysteine	Homo sapiens	-	CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-NTA agarose column chromatography and Superdex 200 gel filtration	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + (R)-4'-phosphopantothenate + L-cysteine	-	Homo sapiens	AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine	-	?
CTP + (R)-4'-phosphopantothenate + L-cysteine	-	Homo sapiens	CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine	-	?

Synonyms

Synonyms	Comment	Organism
CoaB	-	Homo sapiens
phosphopantothenoylcysteine synthetase	-	Homo sapiens
PPCS	-	Homo sapiens

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Release 2023.1 (January 2023)