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Literature summary for 6.3.2.49 extracted from

  • Senoo, A.; Tabata, K.; Yonetani, Y.; Yagasaki, M.
    Identification of novel L-amino acid alpha-ligases through hidden markov model-based profile analysis (2010), Biosci. Biotechnol. Biochem., 74, 415-418.
    View publication on PubMed
Search for more literature for 6.3.2.49

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Streptococcus mutans
expression in Escherichia coli Actinobacillus pleuropneumoniae
expression in Escherichia coli Treponema denticola
expression in Escherichia coli Photorhabdus laumondii subsp. laumondii
expression in Escherichia coli Streptococcus pneumoniae

Organism

Organism UniProt Comment Textmining
Actinobacillus pleuropneumoniae
-
-
-
Photorhabdus laumondii subsp. laumondii Q7N7D2
-
-
Streptococcus mutans
-
-
-
Streptococcus pneumoniae A0A0H2UPI3
-
-
Treponema denticola Q73KK9
-
-

Purification (Commentary)

Purification (Comment) Organism
His Trap Streptococcus mutans
His Trap Actinobacillus pleuropneumoniae
His Trap Treponema denticola
His Trap Photorhabdus laumondii subsp. laumondii
His Trap Streptococcus pneumoniae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2 L-cysteine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-cysteinyl-L-cysteine
-
 ?
ATP + alanine + alanine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-alanyl-L-alanine
-
 ?
ATP + arginine + histidine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-arginyl-L-histidine
-
 ?
ATP + arginine + methionine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-arginyl-L-methionine
-
 ?
ATP + arginine + phenylalanine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-arginyl-L-phenylalanine
-
 ?
ATP + arginine + phenylalanine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-arginyl-L-phenylalanine
-
 ?
ATP + arginine + phenylalanine assay at pH 8.0, 37°C Streptococcus pneumoniae ADP + phosphate + L-arginyl-L-phenylalanine
-
 ?
ATP + arginine + tryptophan assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-arginyl-L-tryptophan
-
 ?
ATP + arginine + tryptophan assay at pH 8.0, 37°C Streptococcus pneumoniae ADP + phosphate + L-arginyl-L-tryptophan
-
 ?
ATP + arginine + tyrosine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-arginyl-L-tyrosine
-
 ?
ATP + cysteine + alanine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-cysteinyl-L-alanine
-
 ?
ATP + cysteine + glutamic acid assay at pH 8.0, 37°C Treponema denticola ADP + phosphate + ?
-
 ?
ATP + cysteine + glutamic acid assay at pH 8.0, 37°C Photorhabdus laumondii subsp. laumondii ADP + phosphate + ?
-
 ?
ATP + cysteine + serine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-cysteinyl-L-serine
-
 ?
ATP + cysteine + threonine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-cysteinyl-L-threonine
-
 ?
ATP + glutamic acid + leucine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + ?
-
 ?
ATP + glutamine + glutamic acid assay at pH 8.0, 37°C Photorhabdus laumondii subsp. laumondii ADP + phosphate + ?
-
 ?
ATP + glutamine + phenylalanine assay at pH 8.0, 37°C Photorhabdus laumondii subsp. laumondii ADP + phosphate + L-glutaminyl-L-phenylalanine
-
 ?
ATP + glycine + L-proline assay at pH 8.0, 37°C Treponema denticola ADP + phosphate + glycyl-L-proline
-
 ?
ATP + histidine + alanine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-histidyl-L-alanine
-
 ?
ATP + histidine + alanine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-histidyl-L-alanine
-
 ?
ATP + histidine + asparagine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-histidyl-L-asparagine
-
 ?
ATP + histidine + cysteine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-histidyl-L-cysteine
-
 ?
ATP + histidine + cysteine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-histidyl-L-cysteine
-
 ?
ATP + histidine + glutamine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-histidyl-L-glutamine
-
 ?
ATP + histidine + histidine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-histidyl-L-histidine
-
 ?
ATP + histidine + methionine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-histidyl-L-methionine
-
 ?
ATP + histidine + phenylalanine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-histidyl-L-phenylalanine
-
 ?
ATP + histidine + phenylalanine assay at pH 8.0, 37°C Streptococcus pneumoniae ADP + phosphate + L-histidyl-L-phenylalanine
-
 ?
ATP + histidine + proline assay at pH 8.0, 37°C Treponema denticola ADP + phosphate + L-histidyl-L-proline
-
 ?
ATP + histidine + proline assay at pH 8.0, 37°C Streptococcus pneumoniae ADP + phosphate + L-histidyl-L-proline
-
 ?
ATP + histidine + serine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-histidyl-L-serine
-
 ?
ATP + histidine + serine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-histidyl-L-serine
-
 ?
ATP + histidine + tryptophan assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-histidyl-L-tryptophan
-
 ?
ATP + histidine + valine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-histidyl-L-valine
-
 ?
ATP + isoleucine + alanine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-isoleucyl-L-alanine
-
 ?
ATP + isoleucine + cysteine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-isoleucyl-L-cysteine
-
 ?
ATP + isoleucine + serine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-isoleucyl-L-serine
-
 ?
ATP + L-asparagine + L-leucine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-asparaginyl-L-leucine
-
 ?
ATP + L-asparagine + L-phenylalanine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-asparaginyl-L-phenylalanine
-
 ?
ATP + L-asparagine + L-phenylalanine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-asparaginyl-L-phenylalanine
-
 ?
ATP + L-asparagine + L-tryptophan assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-asparaginyl-L-tryptophan
-
 ?
ATP + L-cysteine + glycine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-cysteinyl-glycine
-
 ?
ATP + L-glutamine + L-alanine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-glutaminyl-L-alanine
-
 ?
ATP + L-glutamine + L-leucine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-glutaminyl-L-leucine
-
 ?
ATP + L-glutamine + L-methionine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-glutaminyl-L-methionine
-
 ?
ATP + L-glutamine + L-phenylalanine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-glutaminyl-L-phenylalanine
-
 ?
ATP + L-glutamine + L-phenylalanine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-glutaminyl-L-phenylalanine
-
 ?
ATP + L-glutamine + L-tryptophan assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-glutaminyl-L-tryptophan
-
 ?
ATP + L-histidine + glycine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-histidyl-glycine
-
 ?
ATP + L-leucine + glycine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-leucyl-glycine
-
 ?
ATP + L-leucine + glycine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-leucyl-glycine
-
 ?
ATP + L-leucine + glycine assay at pH 8.0, 37°C Streptococcus pneumoniae ADP + phosphate + L-leucyl-glycine
-
 ?
ATP + L-methionine + glycine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-methionyl-glycine
-
 ?
ATP + L-methionine + glycine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-methionyl-glycine
-
 ?
ATP + L-phenylalanine + glycine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-phenylalanyl-glycine
-
 ?
ATP + L-phenylalanine + glycine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-phenylalanyl-glycine
-
 ?
ATP + L-phenylalanine + glycine assay at pH 8.0, 37°C Streptococcus pneumoniae ADP + phosphate + L-phenylalanyl-glycine
-
 ?
ATP + L-tryptophan + glycine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-tryptophanyl-glycine
-
 ?
ATP + L-tryptophan + glycine assay at pH 8.0, 37°C Streptococcus pneumoniae ADP + phosphate + L-tryptophanyl-glycine
-
 ?
ATP + L-tyrosine + glycine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-tyrosinyl-glycine
-
 ?
ATP + leucine + alanine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-leucyl-L-alanine
-
 ?
ATP + leucine + cysteine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-leucyl-L-cysteine
-
 ?
ATP + leucine + cysteine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-leucyl-L-cysteine
-
 ?
ATP + leucine + serine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-leucyl-L-serine
-
 ?
ATP + leucine + threonine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-leucyl-L-threonine
-
 ?
ATP + lysine + histidine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-lysyl-L-histidine
-
 ?
ATP + lysine + phenylalanine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-lysyl-L-phenylalanine
-
 ?
ATP + methionine + alanine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-methionyl-L-alanine
-
 ?
ATP + methionine + cysteine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-methionyl-L-cysteine
-
 ?
ATP + methionine + cysteine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-methionyl-L-cysteine
-
 ?
ATP + methionine + isoleucine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-methionyl-L-isoleucine
-
 ?
ATP + methionine + leucine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-methionyl-L-leucine
-
 ?
ATP + methionine + methionine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-methionyl-L-methionine
-
 ?
ATP + methionine + serine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-methionyl-L-serine
-
 ?
ATP + methionine + threonine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-methionyl-L-threonine
-
 ?
ATP + methionine + valine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-methionyl-L-valine
-
 ?
ATP + phenylalanine + alanine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-phenylalanyl-L-alanine
-
 ?
ATP + phenylalanine + alanine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-phenylalanyl-L-alanine
-
 ?
ATP + phenylalanine + cysteine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-phenylalanyl-L-cysteine
-
 ?
ATP + phenylalanine + cysteine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-phenylalanyl-L-cysteine
-
 ?
ATP + phenylalanine + cysteine assay at pH 8.0, 37°C Streptococcus pneumoniae ADP + phosphate + L-phenylalanyl-L-cysteine
-
 ?
ATP + phenylalanine + isoleucine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-phenylalanyl-L-isoleucine
-
 ?
ATP + phenylalanine + methionine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-phenylalanyl-L-methionine
-
 ?
ATP + phenylalanine + methionine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-phenylalanyl-L-methionine
-
 ?
ATP + phenylalanine + phenylalanine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-phenylalanyl-L-phenylalanine
-
 ?
ATP + phenylalanine + phenylalanine assay at pH 8.0, 37°C Streptococcus pneumoniae ADP + phosphate + L-phenylalanyl-L-phenylalanine
-
 ?
ATP + phenylalanine + serine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-phenylalanyl-L-serine
-
 ?
ATP + phenylalanine + serine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-phenylalanyl-L-serine
-
 ?
ATP + phenylalanine + threonine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-phenylalanyl-L-threonine
-
 ?
ATP + phenylalanine + valine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-phenylalanyl-L-valine
-
 ?
ATP + serine + alanine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-serinyl-L-alanine
-
 ?
ATP + serine + serine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-serinyl-L-serine
-
 ?
ATP + tryptophan + alanine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-tryptophanyl-L-alanine
-
 ?
ATP + tryptophan + alanine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-tryptophanyl-L-alanine
-
 ?
ATP + tryptophan + alanine assay at pH 8.0, 37°C Streptococcus pneumoniae ADP + phosphate + L-tryptophanyl-L-alanine
-
 ?
ATP + tryptophan + cysteine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-tryptophanyl-L-cysteine
-
 ?
ATP + tryptophan + cysteine assay at pH 8.0, 37°C Streptococcus pneumoniae ADP + phosphate + L-tryptophanyl-L-cysteine
-
 ?
ATP + tryptophan + isoleucine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-tryptophanyl-L-isoleucine
-
 ?
ATP + tryptophan + leucine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-tryptophanyl-L-leucine
-
 ?
ATP + tryptophan + methionine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-tryptophanyl-L-methionine
-
 ?
ATP + tryptophan + phenylalanine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-tryptophanyl-L-phenylalanine
-
 ?
ATP + tryptophan + serine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-tryptophanyl-L-serine
-
 ?
ATP + tryptophan + serine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-tryptophanyl-L-serine
-
 ?
ATP + tryptophan + threonine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-tryptophanyl-L-threonine
-
 ?
ATP + tryptophan + tryptophan assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-tryptophanyl-L-tryptophan
-
 ?
ATP + tryptophan + valine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-tryptophanyl-L-valine
-
 ?
ATP + tyrosine + alanine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-tyrosinyl-L-alanine
-
 ?
ATP + tyrosine + alanine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-tyrosinyl-L-alanine
-
 ?
ATP + tyrosine + cysteine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-tyrosinyl-L-cysteine
-
 ?
ATP + tyrosine + methionine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-tyrosinyl-L-methionine
-
 ?
ATP + tyrosine + phenylalanine assay at pH 8.0, 37°C Actinobacillus pleuropneumoniae ADP + phosphate + L-tyrosinyl-L-phenylalanine
-
 ?
ATP + tyrosine + serine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-tyrosinyl-L-serine
-
 ?
ATP + valine + alanine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-valinyl-L-alanine
-
 ?
ATP + valine + serine assay at pH 8.0, 37°C Streptococcus mutans ADP + phosphate + L-valinyl-L-serine
-
 ?

Synonyms

Synonyms Comment Organism
L-amino acid alpha-ligase
-
 Streptococcus mutans
L-amino acid alpha-ligase
-
 Actinobacillus pleuropneumoniae
L-amino acid alpha-ligase
-
 Treponema denticola
L-amino acid alpha-ligase
-
 Photorhabdus laumondii subsp. laumondii
L-amino acid alpha-ligase
-
 Streptococcus pneumoniae
LAL
-
 Streptococcus mutans
LAL
-
 Actinobacillus pleuropneumoniae
LAL
-
 Treponema denticola
LAL
-
 Photorhabdus laumondii subsp. laumondii
LAL
-
 Streptococcus pneumoniae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Streptococcus mutans
37
-
 assay at Actinobacillus pleuropneumoniae
37
-
 assay at Treponema denticola
37
-
 assay at Photorhabdus laumondii subsp. laumondii
37
-
 assay at Streptococcus pneumoniae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Streptococcus mutans
8
-
 assay at Actinobacillus pleuropneumoniae
8
-
 assay at Treponema denticola
8
-
 assay at Photorhabdus laumondii subsp. laumondii
8
-
 assay at Streptococcus pneumoniae