Cloned (Comment) | Organism |
---|---|
gene dll, the ddlR gene is located just upstream of the D-alanyl-D-alanine ligase gene (ddl) in the Brevibacillus brevis genome and the two genes dll and dllR form an operon. Enzyme DllR acts as a transcription factor, and purified DdlR binds specifically to the DNA region that includes putative -35 and -10 regions of the ddlR promoter, a 6-bp inverted repeat that overlaps the -10 region of the ddlR promoter is important for the binding. Phylogenetic tree based on the amino acid sequences of D-alanyl-D-alanine ligases (Ddls) in the proteomes of Escherichia coli and ddlR-positive bacteria | Brevibacillus brevis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Brevibacillus brevis | C0ZB62 | - |
- |
Brevibacillus brevis 47 / JCM 6285 / NBRC 100599 | C0ZB62 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
BBR47_20440 | - |
Brevibacillus brevis |
Ddl | - |
Brevibacillus brevis |
Organism | Comment | Expression |
---|---|---|
Brevibacillus brevis | transcription factor DdlR is an activator of the ddlR-ddl operon, overview. Purified Ddl belongs to the belong to the MocR/GabR family, and is a pyridoxal 5'-phosphate binding transcriptional regulator that has dipeptide binding ability for D-alanyl-D-alanine, the enzymatic product of Ddl, and glycylglycine. DdlR is capable of forming a dipeptide-pyridoxal 5'-phosphate external aldimine, but it lacks aminotransferase activity | up |
General Information | Comment | Organism |
---|---|---|
evolution | phylogenetic tree based on the amino acid sequences of D-alanyl-D-alanine ligases (Ddls) in the proteomes of Escherichia coli and ddlR-positive bacteria, overview. DdlR-mediated transcriptional regulation of ddlR and ddl may occur in multiple bacterial systems such as Actinobacteria and Bacillus species | Brevibacillus brevis |
additional information | transcription factor DdlR, encoded by gene BBR47_28450, is an activator of the ddlR-ddl operon, overview. Purified Ddl belongs to the MocR/GabR family, and is a pyridoxal 5'-phosphate binding transcriptional regulator that has dipeptide binding ability for D-alanyl-D-alanine, the enzymatic product of Ddl, and glycylglycine. DdlR is capable of forming a dipeptide-pyridoxal 5'-phosphate external aldimine, but it lacks aminotransferase activity. DdlR-mediated transcriptional regulation of ddlR and ddl may occur in multiple bacterial systems such as Actinobacteria and Bacillus species | Brevibacillus brevis |