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Literature summary for 6.3.2.4 extracted from

  • Takenaka, T.; Ito, T.; Miyahara, I.; Hemmi, H.; Yoshimura, T.
    A new member of MocR/GabR-type PLP-binding regulator of D-alanyl-D-alanine ligase in Brevibacillus brevis (2015), FEBS J., 282, 4201-4217 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene dll, the ddlR gene is located just upstream of the D-alanyl-D-alanine ligase gene (ddl) in the Brevibacillus brevis genome and the two genes dll and dllR form an operon. Enzyme DllR acts as a transcription factor, and purified DdlR binds specifically to the DNA region that includes putative -35 and -10 regions of the ddlR promoter, a 6-bp inverted repeat that overlaps the -10 region of the ddlR promoter is important for the binding. Phylogenetic tree based on the amino acid sequences of D-alanyl-D-alanine ligases (Ddls) in the proteomes of Escherichia coli and ddlR-positive bacteria Brevibacillus brevis

Organism

Organism UniProt Comment Textmining
Brevibacillus brevis C0ZB62
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Brevibacillus brevis 47 / JCM 6285 / NBRC 100599 C0ZB62
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Synonyms

Synonyms Comment Organism
BBR47_20440
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Brevibacillus brevis
Ddl
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Brevibacillus brevis

Expression

Organism Comment Expression
Brevibacillus brevis transcription factor DdlR is an activator of the ddlR-ddl operon, overview. Purified Ddl belongs to the belong to the MocR/GabR family, and is a pyridoxal 5'-phosphate binding transcriptional regulator that has dipeptide binding ability for D-alanyl-D-alanine, the enzymatic product of Ddl, and glycylglycine. DdlR is capable of forming a dipeptide-pyridoxal 5'-phosphate external aldimine, but it lacks aminotransferase activity up

General Information

General Information Comment Organism
evolution phylogenetic tree based on the amino acid sequences of D-alanyl-D-alanine ligases (Ddls) in the proteomes of Escherichia coli and ddlR-positive bacteria, overview. DdlR-mediated transcriptional regulation of ddlR and ddl may occur in multiple bacterial systems such as Actinobacteria and Bacillus species Brevibacillus brevis
additional information transcription factor DdlR, encoded by gene BBR47_28450, is an activator of the ddlR-ddl operon, overview. Purified Ddl belongs to the MocR/GabR family, and is a pyridoxal 5'-phosphate binding transcriptional regulator that has dipeptide binding ability for D-alanyl-D-alanine, the enzymatic product of Ddl, and glycylglycine. DdlR is capable of forming a dipeptide-pyridoxal 5'-phosphate external aldimine, but it lacks aminotransferase activity. DdlR-mediated transcriptional regulation of ddlR and ddl may occur in multiple bacterial systems such as Actinobacteria and Bacillus species Brevibacillus brevis