Literature summary for 6.3.2.4 extracted from

Greenlee, W.J.; Springer, J.P.; Patchett, A.A.
Synthesis of an analogue of tabtoxinine as a potential inhibitor of the D-alanine:D-alanine ligase (ADP forming) (1989), J. Med. Chem., 32, 165-170.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Tabtoxinine	no inhibition by the lactam analogues	Enterococcus faecalis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + Ala + Ala	Enterococcus faecalis	second step in the biosynthesis of bacterial peptidoglycan	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Enterococcus faecalis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + Ala + Ala	second step in the biosynthesis of bacterial peptidoglycan	Enterococcus faecalis	?	-	?
ATP + D-Ala + D-Ala	-	Enterococcus faecalis	ADP + phosphate + D-Ala-D-Ala	-	?

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Release 2023.1 (January 2023)