BRENDA - Enzyme Database
show all sequences of 6.3.2.39

The isolation and characterization of a hydroxamic acid (aerobactin) formed by Aerobacter aerogenes 62-I

Gibson, F.; Magrath, D.I.; Biochim. Biophys. Acta 192, 175-184 (1969)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2 ATP + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine + N6-acetyl-N6-hydroxy-L-lysine + H2O
Klebsiella aerogenes
the enzyme catalyses the second of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate in biosynthesis of aerobactin. Aerobactin is excreted by cultures of Aerobacter aerogenes 62-I and related strains when growing in an iron-deficient medium
2 ADP + 2 phosphate + aerobactin
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-
?
2 ATP + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine + N6-acetyl-N6-hydroxy-L-lysine + H2O
Klebsiella aerogenes 62-1
the enzyme catalyses the second of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate in biosynthesis of aerobactin. Aerobactin is excreted by cultures of Aerobacter aerogenes 62-I and related strains when growing in an iron-deficient medium
2 ADP + 2 phosphate + aerobactin
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-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Klebsiella aerogenes
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Klebsiella aerogenes 62-1
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Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2 ATP + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine + N6-acetyl-N6-hydroxy-L-lysine + H2O
the enzyme catalyses the second of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate in biosynthesis of aerobactin. Aerobactin is excreted by cultures of Aerobacter aerogenes 62-I and related strains when growing in an iron-deficient medium
719001
Klebsiella aerogenes
2 ADP + 2 phosphate + aerobactin
-
-
-
?
2 ATP + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine + N6-acetyl-N6-hydroxy-L-lysine + H2O
the enzyme catalyses the second of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate in biosynthesis of aerobactin. Aerobactin is excreted by cultures of Aerobacter aerogenes 62-I and related strains when growing in an iron-deficient medium
719001
Klebsiella aerogenes 62-1
2 ADP + 2 phosphate + aerobactin
-
-
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?
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2 ATP + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine + N6-acetyl-N6-hydroxy-L-lysine + H2O
Klebsiella aerogenes
the enzyme catalyses the second of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate in biosynthesis of aerobactin. Aerobactin is excreted by cultures of Aerobacter aerogenes 62-I and related strains when growing in an iron-deficient medium
2 ADP + 2 phosphate + aerobactin
-
-
?
2 ATP + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine + N6-acetyl-N6-hydroxy-L-lysine + H2O
Klebsiella aerogenes 62-1
the enzyme catalyses the second of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate in biosynthesis of aerobactin. Aerobactin is excreted by cultures of Aerobacter aerogenes 62-I and related strains when growing in an iron-deficient medium
2 ADP + 2 phosphate + aerobactin
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2 ATP + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine + N6-acetyl-N6-hydroxy-L-lysine + H2O
the enzyme catalyses the second of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate in biosynthesis of aerobactin. Aerobactin is excreted by cultures of Aerobacter aerogenes 62-I and related strains when growing in an iron-deficient medium
719001
Klebsiella aerogenes
2 ADP + 2 phosphate + aerobactin
-
-
-
?
2 ATP + N2-citryl-N6-acetyl-N6-hydroxy-L-lysine + N6-acetyl-N6-hydroxy-L-lysine + H2O
the enzyme catalyses the second of two synthase reactions to link N6-acetyl-N6-hydroxy-L-lysine and citrate in biosynthesis of aerobactin. Aerobactin is excreted by cultures of Aerobacter aerogenes 62-I and related strains when growing in an iron-deficient medium
719001
Klebsiella aerogenes 62-1
2 ADP + 2 phosphate + aerobactin
-
-
-
?
Other publictions for EC 6.3.2.39
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
719292
Challis
A widely distributed bacterial ...
Escherichia coli
ChemBioChem
6
601-611
2005
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486099
Lorenzo de
Aerobactin biosynthesis and tr ...
Escherichia coli
J. Bacteriol.
165
570-578
1986
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720473
Gross
Identification of the genes an ...
Escherichia coli
Mol. Gen. Genet.
201
204-212
1985
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492296
Appanna
-
Aerobactin synthesis in a cell ...
Klebsiella aerogenes, Klebsiella aerogenes 62-1
Biochim. Biophys. Acta
801
437-443
1984
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719001
Gibson
The isolation and characteriza ...
Klebsiella aerogenes, Klebsiella aerogenes 62-1
Biochim. Biophys. Acta
192
175-184
1969
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