Protein Variants | Comment | Organism |
---|---|---|
L534A/P535A | site-directed mutagenesis, the mutant shows properties similar to GSH synthetase, EC 6.3.2.3. A534 and A535 are conserved in glutathione synthetase | Medicago truncatula |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + gamma-L-glutamyl-L-cysteine + beta-alanine | Medicago truncatula | - |
ADP + phosphate + gamma-L-glutamyl-L-cysteinyl-beta-alanine | - |
? | |
ATP + gamma-L-glutamyl-L-cysteine + L-serine | Medicago truncatula | - |
ADP + phosphate + gamma-L-glutamyl-L-cysteinyl-L-serine | - |
? | |
additional information | Medicago truncatula | hGSH synthetase found in plants is much more specific for beta-Ala, although it also accepts Gly as a substrate | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Medicago truncatula | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + gamma-L-glutamyl-L-cysteine + beta-alanine | - |
Medicago truncatula | ADP + phosphate + gamma-L-glutamyl-L-cysteinyl-beta-alanine | - |
? | |
ATP + gamma-L-glutamyl-L-cysteine + beta-alanine | - |
Medicago truncatula | ADP + phosphate + gamma-L-glutamyl-L-cysteinyl-beta-alanine | i.e. homo-glutathione | ? | |
ATP + gamma-L-glutamyl-L-cysteine + L-serine | - |
Medicago truncatula | ADP + phosphate + gamma-L-glutamyl-L-cysteinyl-L-serine | - |
? | |
ATP + gamma-L-glutamyl-L-cysteine + L-serine | - |
Medicago truncatula | ADP + phosphate + gamma-L-glutamyl-L-cysteinyl-L-serine | i.e. hydroxymethyl-glutathione | ? | |
additional information | hGSH synthetase found in plants is much more specific for beta-Ala, although it also accepts Gly as a substrate | Medicago truncatula | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
hGSH synthetase | - |
Medicago truncatula |
hGSH-synthetase | - |
Medicago truncatula |
homoglutathione synthetase | - |
Medicago truncatula |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Medicago truncatula |
General Information | Comment | Organism |
---|---|---|
evolution | homoglutathione synthetase has evolved from glutathione synthetase, EC 6.3.2.3, by a single gene duplication event | Medicago truncatula |