Literature summary for 6.3.2.2 extracted from

Henriquez, F.L.; Campbell, S.A.; Roberts, C.W.; Mullen, A.B.; Burchmore, R.; Carter, K.C.
Vaccination with recombinant Leishmania donovani gamma-glutamylcysteine synthetase fusion protein protects against L. donovani infection (2010), J. Parasitol., 96, 929-936.

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Application

Application	Comment	Organism
medicine	study on recombinant Leishmania donovani gammaglutamyl cysteine synthetase protein alone or incorporated into a non-ionic surfactant vesicle delivery system to protect against Leishmania donovani infection in a BALB/c mouse model. Immunization with gammaglutamyl cysteine synthetase alone or gammaglutamyl cysteine synthetase-NIV induces specific IgG1 and IgG2a antibodies compared to controls, with gammaglutamyl cysteine synthetase-NIV inducing significantly higher titers of both antibody classes. Both formulations induce similar increases in splenocyte IFN-gamma production following ex vivo antigen stimulation with gammaglutamyl cysteine synthetase compared with cells from control mice. Similar levels of protection against infection are induced by gammaglutamyl cysteine synthetase alone and gammaglutamyl cysteine synthetase-NIV, based on their ability to suppress liver parasite burdens compared to control values	Leishmania donovani

Organism

Organism	UniProt	Comment	Textmining
Leishmania donovani	-	-	-

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Release 2023.1 (January 2023)