Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.3.2.2 extracted from

  • Morita, M.; Akai, S.; Hosomi, H.; Tsuneyama, K.; Nakajima, M.; Yokoi, T.
    Drug-induced hepatotoxicity test using gamma-glutamylcysteine synthetase knockdown rat (2009), Toxicol. Lett., 189, 159-165.
    View publication on PubMed

Application

Application Comment Organism
pharmacology rat model of glutathione depletion using an adenovirus vector with short hairpin RNA against gamma-glutamylcysteine synthetase heavy chain subunit. In the acute 6 or 24 h or subacute 7 days toxicity tests, rats were administered the drugs once or once a day for a week, respectively. Plasma biochemical markers for hepatotoxicity were measured. The 6 and 24 h toxicity test of diclofenac, and the 24 h and 7 days toxicity tests of flutamide show significant serum alanine aminotransferase elevations. The 24 h toxicity test of flutamide shows a slight bilirubin elevation, and histological hepatotoxicity. The 7 days toxicity test of flutamide also demonstrates histological hepatotoxicity Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-