Application | Comment | Organism |
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pharmacology | rat model of glutathione depletion using an adenovirus vector with short hairpin RNA against gamma-glutamylcysteine synthetase heavy chain subunit. In the acute 6 or 24 h or subacute 7 days toxicity tests, rats were administered the drugs once or once a day for a week, respectively. Plasma biochemical markers for hepatotoxicity were measured. The 6 and 24 h toxicity test of diclofenac, and the 24 h and 7 days toxicity tests of flutamide show significant serum alanine aminotransferase elevations. The 24 h toxicity test of flutamide shows a slight bilirubin elevation, and histological hepatotoxicity. The 7 days toxicity test of flutamide also demonstrates histological hepatotoxicity | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
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Rattus norvegicus | - |
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