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Literature summary for 6.3.2.2 extracted from

  • Gao, S.S.; Choi, B.M.; Chen, X.Y.; Zhu, R.Z.; Kim, Y.; So, H.; Park, R.; Sung, M.; Kim, B.R.
    Kaempferol suppresses cisplatin-induced apoptosis via inductions of heme oxygenase-1 and glutamate-cysteine ligase catalytic subunit in HEI-OC1 cell (2010), Pharm. Res., 27, 235-245.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
HEI-OC1 cell auditory cell Mus musculus
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Expression

Organism Comment Expression
Mus musculus kaempferol protects cells against cisplatin-induced apoptosis in a dose-dependent manner in HEI-OC1 cells. Kaempferol increases the cellular level of glutathione and the expression of GCL catalytic subunit time-dependently. siRNA directed against GCL catalytic subunit blocks the increase of glutathione level by kaempferol and the protective effect of kaempferol against cisplatin-induced cell death up