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Literature summary for 6.3.2.2 extracted from

  • Botta, D.; White, C.C.; Vliet-Gregg, P.; Mohar, I.; Shi, S.; McGrath, M.B.; McConnachie, L.A.; Kavanagh, T.J.
    Modulating GSH synthesis using glutamate cysteine ligase transgenic and gene-targeted mice (2008), Drug Metab. Rev., 40, 465-477.
    View publication on PubMed
Search for more literature for 6.3.2.2

Cloned(Commentary)

Cloned (Comment) Organism
genes gclC and gclM, genotyping and expression analysis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information transgenic mice that conditionally overexpress GCL subunits are protected from acetaminophen induced liver injury. Gclm null mice exhibit low GSH levels and enhanced sensitivity to acetaminophen. When Gclm expression and GCL activity are restored in Gclm conditional transgenic X Gclm null mice, they become resistant to APAP-induced liver damage. Construction of transgenic mouse models of inducible GCL subunit expression in the liver, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
glutathione the cataytic subunit GCLC is feddback inhibited by GSH Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-glutamate + L-cysteine Mus musculus first step in glutathione biosynthesis ADP + phosphate + gamma-L-glutamyl-L-cysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 gene gclC and gclM, encoding the catalytic and the modifier subunit
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-glutamate + L-cysteine
-
 Mus musculus ADP + phosphate + gamma-L-glutamyl-L-cysteine
-
 ?
ATP + L-glutamate + L-cysteine first step in glutathione biosynthesis Mus musculus ADP + phosphate + gamma-L-glutamyl-L-cysteine
-
 ?

Subunits

Subunits Comment Organism
dimer GCL is composed of catalytic GCLC and modifier GCLM subunits Mus musculus

Synonyms

Synonyms Comment Organism
GCL
-
 Mus musculus
glutamate cysteine ligase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus