Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | induction of Gclc by homocysteine, ARE4 plays a direct role in mediating the induction, Nrf2 signalling is critical in homocysteine-induced activation of ARE4, overview | Mus musculus |
Cloned (Comment) | Organism |
---|---|
genes gclC and gclM, DNA and amino acid sequence determination and analysis | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | ARE-driven gene expression of Gclc via a MEK/Nrf2 pathway can help to protect macrophages from oxidative stress due to hyperhomocysteinemia | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
genes gclC and gclM | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | - |
Mus musculus | - |
RAW-264.7 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | ARE-driven gene expression of Gclc via a MEK/Nrf2 pathway can help to protect macrophages from oxidative stress due to hyperhomocysteinemia | Mus musculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | heterodimer consisting of catalytic and modifier subunits GCLC and GCLM | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
GCL | - |
Mus musculus |
glutamate cysteine ligase | - |
Mus musculus |