Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.3.2.2 extracted from

  • Kishi, T.; Ikeda, M.; Kitajima, T.; Yamanouchi, Y.; Kinoshita, Y.; Kawashima, K.; Inada, T.; Harano, M.; Komiyama, T.; Hori, T.; Yamada, M.; Iyo, M.; Sora, I.; Sekine, Y.; Ozaki, N.; Ujike, H.; Iwata, N.
    Glutamate cysteine ligase modifier (GCLM) subunit gene is not associated with methamphetamine-use disorder or schizophrenia in the Japanese population (2008), Ann. N. Y. Acad. Sci., 1139, 63-69.
    View publication on PubMed
Search for more literature for 6.3.2.2

Cloned(Commentary)

Cloned (Comment) Organism
genes gclC and gclM, genotyping in healthy individuals and in schizophrenia patients, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-glutamate + L-cysteine Homo sapiens GCL is the key glutathione-synthesizing enzyme ADP + phosphate + gamma-L-glutamyl-L-cysteine
-
 ?
additional information Homo sapiens the modifier subunit GCLM is not correlated with methamphetamine-use disorder or schizophrenia in the Japanese population, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 Japanese individuals and patients with methamphetamine dependence and induced psychosis, genes gclC and gclM encoding the catalytic and the modifier subunit of the enzyme
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-glutamate + L-cysteine
-
 Homo sapiens ADP + phosphate + gamma-L-glutamyl-L-cysteine
-
 ?
ATP + L-glutamate + L-cysteine GCL is the key glutathione-synthesizing enzyme Homo sapiens ADP + phosphate + gamma-L-glutamyl-L-cysteine
-
 ?
additional information the modifier subunit GCLM is not correlated with methamphetamine-use disorder or schizophrenia in the Japanese population, overview Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
dimer the enzyme consists of a catalytic subunit GCLC and a modifier subunit GCLM Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens