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Literature summary for 6.3.2.2 extracted from

  • Das, G.C.; Bacsi, A.; Shrivastav, M.; Hazra, T.K.; Boldogh, I.
    Enhanced gamma-glutamylcysteine synthetase activity decreases drug-induced oxidative stress levels and cytotoxicity (2006), Mol. Carcinog., 45, 635-647.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-glutamate + L-cysteine Homo sapiens overexpression of gamma-GCS decreases drug-induced oxidative stress and confers drug resistance ADP + phosphate + gamma-L-glutamyl-L-cysteine
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
A2780/100 cell A2780/100 ovarian carcinoma cell exhibits resistance to DNA crosslinking agents, chlorambucil, cisplatin, melphalan, and ionizing radiation compared to the parental cell line, A2780. Drug-resistant cells have the inherent ability to maintain increased gamma-GCS activity Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-glutamate + L-cysteine overexpression of gamma-GCS decreases drug-induced oxidative stress and confers drug resistance Homo sapiens ADP + phosphate + gamma-L-glutamyl-L-cysteine
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?

Synonyms

Synonyms Comment Organism
gamma-GCS
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Homo sapiens