Literature summary for 6.3.2.2 extracted from

Takamura, Y.; Fatma, N.; Kubo, E.; Singh, D.P.
Regulation of heavy subunit chain of gamma-glutamylcysteine synthetase by tumor necrosis factor-alpha in lens epithelial cells: role of LEDGF/p75 (2006), Am. J. Physiol., 290, C554-C566.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-glutamate + L-cysteine	evidence of TNF-alpha-mediated LEDGF induction of gamma-glutamylcysteine synthetase heavy subunit and mRNA expression. TNF-alpha-induced intracellular level of reactive oxygen species is critical for the regulation of the multidomain adaptor protein LEDGF, which subsequently influences cellular glutathione content by regulating transcription of gamma-glutamylcysteine synthetase heavy subunit	Homo sapiens	ADP + phosphate + gamma-L-glutamyl-L-cysteine	-	?

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Release 2023.1 (January 2023)