Activating Compound | Comment | Organism | Structure |
---|---|---|---|
buthionine sulfoximine | induction of enzyme expression | Rattus norvegicus | |
diethyl maleate | induction of enzyme expression | Rattus norvegicus | |
ethanol | feeding in vivo increases the enzyme expression, treatment of hepatocytes induces the expression of only the heavy enzyme subunit | Rattus norvegicus | |
hydrocortisone | treatment of hepatocytes induces the expression of only the heavy enzyme subunit | Rattus norvegicus | |
Insulin | treatment of hepatocytes induces the expression of only the heavy enzyme subunit | Rattus norvegicus | |
additional information | two-thirds partial hepatectomy increases the enzyme expression | Rattus norvegicus | |
tert-butylhydroquinone | induction of enzyme expression | Rattus norvegicus | |
Thioacetamide | induction of enzyme expression | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-Glu + L-Cys | Rattus norvegicus | first step in glutathione biosynthesis | ADP + phosphate + gamma-L-Glu-L-Cys | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | primary cell culture | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-Glu + L-Cys | - |
Rattus norvegicus | ADP + phosphate + gamma-L-Glu-L-Cys | - |
? | |
ATP + L-Glu + L-Cys | first step in glutathione biosynthesis | Rattus norvegicus | ADP + phosphate + gamma-L-Glu-L-Cys | - |
? |
Synonyms | Comment | Organism |
---|---|---|
gamma-Glutamylcysteine synthetase | - |
Rattus norvegicus |
GCS | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |