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Literature summary for 6.3.2.17 extracted from

  • Gomez-Gomez, Y.; Organista-Nava, J.; Rangel-Rodriguez, C.A.; Illades-Aguiar, B.; Moreno-Godinez, M.E.; Alarcon-Romero, L.D.; Leyva-Vazquez, M.A.
    Effect of folylpolyglutamate synthase A22G polymorphism on the risk and survival of patients with acute lymphoblastic leukemia (2014), Oncol. Lett., 8, 731-735 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.3.2.17

Cloned(Commentary)

Cloned (Comment) Organism
gene FPGS, genotyping in different human populations Homo sapiens

Protein Variants

Protein Variants Comment Organism
A22G a naturally occuring mutation, rs10760502 , phenotype, overview. The genotypes of the A22G polymorphism may be risk factors for acute lymphoblastic leukemia (ALL) and may play a role in the survival of patients with ALL Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + methotrexate + L-glutamate Homo sapiens
-
 ADP + phosphate + L-glutamyl-methotrexate
-
 ?
ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate Homo sapiens
-
 ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow
-
 Homo sapiens
-
peripheral blood cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + methotrexate + L-glutamate
-
 Homo sapiens ADP + phosphate + L-glutamyl-methotrexate
-
 ?
ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate
-
 Homo sapiens ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1
-
 ?

Synonyms

Synonyms Comment Organism
Folylpolyglutamate synthase
-
 Homo sapiens
FPGS
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction the A22G polymorphism in the FPGS gene is associated with an increased risk of acute lymphoblastic leukemia (ALL) and plays a role in increasing the survival of patients with ALL, effects of folylpolyglutamate synthase A22G polymorphism on the risk and survival of patients with acute lymphoblastic leukemia, overview Homo sapiens
physiological function folylpolyglutamate synthase (FPGS) is the key enzyme that converts the chemotherapeutic agent, methotrexate (MTX), into MTX polyglutamate Homo sapiens