Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell nucleus | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CCRF-CEM cell | - |
Homo sapiens | - |
NALM-6 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
folypoly-gamma-glutamate synthetase | - |
Homo sapiens |
FPGS | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | 2- to 5fold increased mRNA expression after treatment with sodium butyrate or suberoylanilide hydroxamic acid | up |
General Information | Comment | Organism |
---|---|---|
metabolism | metabolizes methotrexate, a universal component of acute lymphoblastic leukemia, into long-chain poylglutamates, resulting in enhanced cytotoxicity from prolonged inhibition of dihydrofolate reductase and thymidylate synthetase | Homo sapiens |