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Literature summary for 6.3.2.17 extracted from

  • Leclerc, G.J.; Mou, C.; Leclerc, G.M.; Mian, A.M.; Barredo, J.C.
    Histone deacetylase inhibitors induce FPGS mRNA expression and intracellular accumulation of long-chain methotrexate polyglutamates in childhood acute lymphoblastic leukemia: implications for combination therapy (2010), Leukemia, 24, 552-562.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cell nucleus
-
Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CCRF-CEM cell
-
Homo sapiens
-
NALM-6 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
folypoly-gamma-glutamate synthetase
-
Homo sapiens
FPGS
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens 2- to 5fold increased mRNA expression after treatment with sodium butyrate or suberoylanilide hydroxamic acid up

General Information

General Information Comment Organism
metabolism metabolizes methotrexate, a universal component of acute lymphoblastic leukemia, into long-chain poylglutamates, resulting in enhanced cytotoxicity from prolonged inhibition of dihydrofolate reductase and thymidylate synthetase Homo sapiens