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Literature summary for 6.3.2.17 extracted from
- Purification, crystallization and preliminary X-ray analysis of Mycobacterium tuberculosis folylpolyglutamate synthase (MtbFPGS) (2006), Acta Crystallogr. Sect. F, 62, 579-582.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli strain BL21 (DELTADE3) | Mycobacterium tuberculosis |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| batch method in the presence ADP and CoCl2 or vapour diffusion in the presence of ADP, dihydrofolate and CaCl2 | Mycobacterium tuberculosis |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50900 | - |
predicted from amino acid sequence | Mycobacterium tuberculosis |
| 51000 | - |
SDS-PAGE | Mycobacterium tuberculosis |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni-Sepharose 6 Fastflow resin chromatography and Superdex-200 gel filtration | Mycobacterium tuberculosis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + (6RS)-5,6,7,8-tetrahydrofolic acid + L-glutamate | - |
Mycobacterium tuberculosis | ADP + phosphate + (6S)-5,6,7,8-tetrahydrofolyl-Glu | - |
ir |  |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 51000, SDS-PAGE | Mycobacterium tuberculosis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Folylpolyglutamate synthase | - |
Mycobacterium tuberculosis |
| FPGS | - |
Mycobacterium tuberculosis |
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